Function:
Functions as a bridging factor between STAT6 and the basal transcription factor. Plays a role in PIM1 regulation of MYB activity. Functions as a transcriptional coactivator for the Epstein-Barr virus nuclear antigen 2 (EBNA2).
Subcellular Location:
Cytoplasm. Nucleus. Melanosome. In IL-4 stimulated cells colocalizes with STAT6 in the nucleus. Identified by mass spectrometry in melanosome fractions from stage I to stage IV.
Tissue Specificity:
Ubiquitously expressed.
Post-translational modifications:
Phosphorylated by PIM1 in vitro.
Similarity:
Contains 4 TNase-like domains.
Contains 1 Tudor domain.
Database links:
Entrez Gene: 472504 Chimpanzee
Entrez Gene: 475204 Dog
Entrez Gene: 27044 Human
Entrez Gene: 56463 Mouse
Entrez Gene: 64635 Rat
Entrez Gene: 699542 Rhesus monkey
Omim: 602181 Human
SwissProt: Q7KZF4 Human
SwissProt: Q78PY7 Mouse
SwissProt: Q5REU4 Orangutan
SwissProt: Q66X93 Rat
Unigene: 122523 Human
Unigene: 439987 Mouse
Unigene: 36148 Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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