background:
The content of phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2) in endosomal membranes changes dynamically with fission and fusion events that generate or absorb intracellular transport vesicles. VAC14 is a component of a trimolecular complex that tightly regulates the level of PtdIns(3,5)P2. Other components of this complex are the PtdIns(3,5)P2-synthesizing enzyme PIKFYVE (MIM 609414) and the PtdIns(3,5)P2 phosphatase FIG4 (MIM 609390). VAC14 functions as an activator of PIKFYVE (Sbrissa et al., 2007 [PubMed 17556371]).[supplied by OMIM, Feb 2010]
Function:
The PI(3,5)P2 regulatory complex regulates both the synthesis and turnover of phosphatidylinositol-3,5-bisphosphate (PtdIns(3,5)P2). Acts as a positive activator of PIKfyve kinase activity. Also required to maintain normal levels of phosphatidylinositol 3-phosphate (PtdIns(3)P) and phosphatidylinositol 5-phosphate (PtdIns(5)P). Plays a role in the biogenesis of endosome carrier vesicles (ECV) / multivesicular bodies (MVB) transport intermediates from early endosomes.
Subcellular Location:
Endosome membrane. Microsome membrane. Mainly associated with membranes of the late endocytic pathway.
Tissue Specificity:
Ubiquitously expressed.
Similarity:
Belongs to the VAC14 family.
Contains 6 HEAT repeats.
Database links:
Entrez Gene: 55697 Human
Entrez Gene: 234729 Mouse
Entrez Gene: 307842 Rat
Omim: 604632 Human
SwissProt: Q08AM6 Human
SwissProt: Q80WQ2 Mouse
SwissProt: Q80W92 Rat
Unigene: 445061 Human
Unigene: 274894 Mouse
Unigene: 46366 Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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