Function:
Probable serine protease which may play a role in cellular senescence. Overexpression inhibits cell growth and induce G1 cell cycle arrest.
Subcellular Location:
Membrane.
Tissue Specificity:
Expressed in esophagus, liver, colon and lung. Down-regulated in esophagus cancers.
Similarity:
Belongs to the peptidase S1 family.
Contains 1 peptidase S1 domain.
Contains 1 SEA domain.
Database links:
Entrez Gene: 339967 Human
Entrez Gene: 194597 Mouse
Entrez Gene: 686581 Rat
Omim: 611704 Human
SwissProt: Q6ZMR5 Human
SwissProt: Q3UQ41 Mouse
Unigene: 450110 Human
Unigene: 249106 Mouse
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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