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Rabbit Anti-SMAD8/FITC Conjugated antibody
background:
The protein encoded by this gene belongs to the SMAD, a family of proteins similar to the gene products of the Drosophila gene 'mothers against decapentaplegic' (Mad) and the C. elegans gene Sma. SMAD proteins are signal transducers and transcriptional modulators that mediate multiple signaling pathways. This protein mediates the signals of the bone morphogenetic proteins (BMPs), which are involved in a range of biological activities including cell growth, apoptosis, morphogenesis, development and immune responses. In response to BMP ligands, this protein can be phosphorylated and activated by the BMP receptor kinase. The phosphorylated form of this protein forms a complex with SMAD4, which is important for its function in the transcription regulation. This protein is a target for SMAD-specific E3 ubiquitin ligases, such as SMURF1 and SMURF2, and undergoes ubiquitination and proteasome-mediated degradation. Alternatively spliced transcript variants encoding the same protein have been observed. [provided by RefSeq, Jul 2008]
Function:
Sphingomyelin synthases synthesize sphingolipids through transfer of a phosphatidyl head group on to the primary hydroxyl of ceramide. SAMD8 is an endoplasmic reticulum (ER) transferase that has no sphingomyelin synthase activity but can convert phosphatidylethanolamine (PE) and ceramide to ceramide phosphoethanolamine (CPE) albeit with low product yield. Appears to operate as a ceramide sensor to control ceramide homeostasis in the endoplasmic reticulum rather than a converter of ceramides. Seems to be critical for the integrity of the early secretory pathway
Subcellular Location:
Cytoplasmic and Nuclear.
Similarity:
Belongs to the sphingomyelin synthase family.
Contains 1 SAM (sterile alpha motif) domain.
Database links:
Entrez Gene: 4086 Human
Entrez Gene: 4090 Human
Entrez Gene: 4093 Human
Entrez Gene: 17125 Mouse
Entrez Gene: 17129 Mouse
Entrez Gene: 55994 Mouse
Entrez Gene: 25671 Rat
Entrez Gene: 59328 Rat
Entrez Gene: 85435 Rat
Omim: 601595 Human
Omim: 603110 Human
Omim: 603295 Human
SwissProt: O15198 Human
SwissProt: Q15797 Human
SwissProt: Q99717 Human
SwissProt: P70340 Mouse
SwissProt: P97454 Mouse
SwissProt: Q9JIW5 Mouse
SwissProt: O54835 Rat
SwissProt: P97588 Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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