Function:
May play a role in early endosome fusion upstream of RAB5, hence regulating receptor trafficking and fluid-phase transport. Enhances cellular sensitivity to TNF-induced apoptosis (PubMed:18288467).
Tissue Specificity:
Expressed in placenta, ovary and small intestine, as well as in heart and pancreas. Also expressed in peripheral blood mononuclear cells and dendritic cells.
Similarity:
Contains 1 FYVE-type zinc finger.
Contains 1 PH domain.
Database links:
Entrez Gene: 420234 Chicken
Entrez Gene: 782597 Cow
Entrez Gene: 79666 Human
Entrez Gene: 7361 Mouse
Entrez Gene: 362484 Rat
SwissProt: Q5ZLY5 Chicken
SwissProt: Q9H8W4 Human
SwissProt: Q91WB4 Mouse
Unigene: 29724 Human
Unigene: 34351 Mouse
Unigene: 11991 Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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