background:
The protein encoded by this gene appears to be a zinc finger protein containing a transposase domain at the SLCterminus. This protein was found to interact with the transcription factor SP1 in a yeast two-hybrid system. Alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Aug 2010]
Function:
Plays a role in mitotic cell cycle progression and is involved in kinetochore assembly and mitotic sister chromatid cohesion. Probably through its association with CBX5 plays a role in mitotic chromosome segregation by regulating aurora kinase B/AURKB activation and AURKB and CBX5 dissociation from chromosome arms.
Subcellular Location:
Nucleus. Chromosome. Cytoplasm. According to some authors, it is not localized to mitotic chromatin (PubMed:1924448). Recruited to trimethylated 'Lys-9' of histone H3.
Similarity:
Contains 9 C2H2-type zinc fingers.
Contains 1 DDE domain.
Contains 1 HTH CENPB-type DNA-binding domain.
Database links:
Entrez Gene: 475849 Dog
Entrez Gene: 23126 Human
Entrez Gene: 229584 Mouse
Entrez Gene: 310658 Rat
Omim: 614787 Human
SwissProt: Q7Z3K3 Human
SwissProt: Q8BZH4 Mouse
Unigene: 489873 Human
Unigene: 274787 Mouse
Unigene: 103975 Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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