Function:
May mediate accelerated ATP-independent bidirectional transbilayer migration of phospholipids upon binding calcium ions that results in a loss of phospholipid asymmetry in the plasma membrane. May play a central role in the initiation of fibrin clot formation, in the activation of mast cells and in the recognition of apoptotic and injured cells by the reticuloendothelial system.
Subcellular Location:
Membrane.
Tissue Specificity:
Expressed in heart, brain, placenta, lung, liver, kidney, pancreas, spleen, thymus, prostate, testis, uterus, small intestine and colon. Not detected in peripheral blood lymphocytes.
Similarity:
Belongs to the phospholipid scramblase family.
Database links:
Entrez Gene: 57088 Human
Entrez Gene: 235527 Mouse
Omim: 607612 Human
SwissProt: Q9NRQ2 Human
SwissProt: P58196 Mouse
Unigene: 477869 Human
Unigene: 55289 Mouse
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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