background:
Vesicle mediated protein sorting plays an important role in segregation of intracellular molecules into distinct organelles. Genetic studies in yeast have identified more than 40 vacuolar protein sorting (VPS) genes involved in vesicle transport to vacuoles. This gene is a member of the Sec1 domain family, and shows a high degree of sequence similarity to mouse, rat and yeast Vps45. The exact function of this gene is not known, but its high expression in peripheral blood mononuclear cells suggests a role in trafficking proteins, including inflammatory mediators. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jul 2013]
Function:
May play a role in vesicle-mediated protein trafficking from the Golgi stack through the trans-Golgi network.
Subcellular Location:
Golgi apparatus membrane. Endosome membrane. Associated with Golgi/endosomal vesicles and the trans-Golgi network.
Tissue Specificity:
Ubiquitous. Expression was highest in testis, heart and brain, intermediate in kidney, spleen, prostate, ovary, small intestine and thymus and low in lung, skeletal muscle, placenta, colon, pancreas, peripheral blood leukocytes and liver.
Similarity:
Belongs to the STXBP/unc-18/SEC1 family.
Database links:
Entrez Gene: 430741 Chicken
Entrez Gene: 11311 Human
Entrez Gene: 22365 Mouse
Entrez Gene: 64516 Rat
Omim: 610035 Human
SwissProt: Q9NRW7 Human
SwissProt: P97390 Mouse
SwissProt: O08700 Rat
Unigene: 443750 Human
Unigene: 263185 Mouse
Unigene: 9316 Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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