background:
This gene encodes a protein that is a subunit of the endosomal sorting complex required for transport II (ESCRT-II). This protein complex functions in sorting of ubiquitinated membrane proteins during endocytosis. A similar protein complex in rat is associated with RNA polymerase elongation factor II. [provided by RefSeq, Aug 2013]
Function:
Component of the ESCRT-II complex (endosomal sorting complex required for transport II), which is required for multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. The MVB pathway mediates delivery of transmembrane proteins into the lumen of the lysosome for degradation. The ESCRT-II complex is probably involved in the recruitment of the ESCRT-III complex. Its ability to bind ubiquitin probably plays a role in endosomal sorting of ubiquitinated cargo proteins by ESCRT complexes. The ESCRT-II complex may also play a role in transcription regulation, possibly via its interaction with ELL. Binds phosphoinosides such as PtdIns(3,4,5)P3.
Subcellular Location:
Cytoplasm. Endosome. Late endosome. Membrane. Nucleus. Colocalizes with ubiquitinated proteins on late endosomes. Recruited to the endosome membrane to participate in vesicle formation.
Similarity:
Belongs to the VPS36 family.
Contains 1 GLUE domain.
Database links:
Entrez Gene: 418883 Chicken
Entrez Gene: 511223 Cow
Entrez Gene: 477292 Dog
Entrez Gene: 51028 Human
Entrez Gene: 70160 Mouse
Entrez Gene: 290851 Rat
Entrez Gene: 335810 Zebrafish
Omim: 610903 Human
SwissProt: A5PK00 Cow
SwissProt: Q86VN1 Human
SwissProt: Q91XD6 Mouse
SwissProt: P0C0A2 Rat
SwissProt: Q7ZVK4 Zebrafish
Unigene: 109520 Human
Unigene: 41453 Mouse
Unigene: 474298 Mouse
Unigene: 12707 Rat
Unigene: 21065 Zebrafish
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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