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Rabbit Anti-SYBL1/FITC Conjugated antibody
background:
FLJ53045;
FLJ53762;
FLJ54296;
HGNC:11486;
OTTHUMP00000024258;
OTTHUMP00000024259;
OTTHUMP00000225953;
SYBL 1;
SYBL1;
Synaptobrevin like 1;
Synaptobrevin-like protein 1;
Tetanus insensitive VAMP;
Tetanus neurotoxin insensitive VAMP;
Tetanus-insensitive VAMP;
TI VAMP;
Ti-VAMP;
TIVAMP;
VAMP-7;
VAMP7;
VAMP7_HUMAN
Function:
Involved in the targeting and/or fusion of transport vesicles to their target membrane during transport of proteins from the early endosome to the lysosome. Required for heterotypic fusion of late endosomes with lysosomes and homotypic lysosomal fusion. Required for calcium regulated lysosomal exocytosis. Involved in the export of chylomicrons from the endoplasmic reticulum to the cis Golgi. Required for exocytosis of mediators during eosinophil and neutrophil degranulation, and target cell killing by natural killer cells. Required for focal exocytosis of late endocytic vesicles during phagosome formation.
Subcellular Location:
Cytoplasmic vesicle > secretory vesicle membrane. Golgi apparatus > trans-Golgi network membrane. Late endosome membrane. Lysosome membrane. Endoplasmic reticulum membrane. Cytoplasmic vesicle > phagosome membrane.
Tissue Specificity:
Detected in all tissues tested.
Similarity:
Belongs to the synaptobrevin family.
Contains 1 longin domain.
Contains 1 v-SNARE coiled-coil homology domain.
Database links:
Entrez Gene: 6845 Human
Entrez Gene: 20955 Mouse
Entrez Gene: 85491 Rat
Omim: 300053 Human
SwissProt: P5369 Human
SwissProt: P70280 Mouse
SwissProt: Q9JHW5 Rat
Unigene: 24167 Human
Unigene: 1517 Mouse
Unigene: 34151 Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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