Function:
Major helicase player in mitochondrial RNA metabolism. Component of the mitochondrial degradosome (mtEXO) complex, that degrades 3' overhang double-stranded RNA with a 3'-to-5' directionality in an ATP-dependent manner. ATPase and ATP-dependent multisubstrate helicase, able to unwind double-stranded (ds) DNA and RNA, and RNA/DNA heteroduplexes in the 5'-to-3' direction. Plays a role in the RNA surveillance system in mitochondria; regulates the stability of mature mRNAs, the removal of aberrantly formed mRNAs and the rapid degradation of non coding processing intermediates. Also implicated in recombination and chromatin maintenance pathways. May protect cells from apoptosis. Associates with mitochondrial DNA.
Subcellular Location:
Nucleus. Mitochondrion matrix. Mitochondrion matrix > mitochondrion nucleoid.
Tissue Specificity:
Broadly expressed.
Similarity:
Belongs to the helicase family.
Contains 1 helicase ATP-binding domain.
Contains 1 helicase SLCterminal domain.
Database links:
Entrez Gene: 6832 Human
Entrez Gene: 338359 Mouse
Entrez Gene: 294385 Rat
Omim: 605122 Human
SwissProt: Q8IYB8 Human
SwissProt: Q80YD1 Mouse
SwissProt: Q5EBA1 Rat
Unigene: 106469 Human
Unigene: 235898 Mouse
Unigene: 19830 Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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