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Rabbit Anti-SURF4/FITC Conjugated antibody
background:
This gene is located in the surfeit gene cluster, which is comprised of very tightly linked housekeeping genes that do not share sequence similarity. The encoded protein is a conserved integral membrane protein that interacts with endoplasmic reticulum-Golgi intermediate compartment proteins. Disruption of this gene results in reduced numbers of endoplasmic reticulum-Golgi intermediate compartment clusters and redistribution of coat protein I to the cytosol. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]
Function:
May play a role in the maintenance of the architecture of the endoplasmic reticulum-Golgi intermediate compartment and of the Golgi.
Subunit:
Found in a complex composed at least of SURF4, TMED2 and TMED10. May interact with LMAN1.
Subcellular Location:
Endoplasmic reticulum membrane. Endoplasmic reticulum-Golgi intermediate compartment membrane. Golgi apparatus membrane. Cycles between the endoplasmic reticulum and the Golgi.
Similarity:
Belongs to the SURF4 family.
Database links:
Entrez Gene: 6836 Human
Entrez Gene: 20932 Mouse
Entrez Gene: 619346 Rat
Omim: 185660 Human
SwissProt: O15260 Human
SwissProt: Q64310 Mouse
Unigene: 512465 Human
Unigene: 300594 Mouse
Unigene: 107863 Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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