Function:
Phosphatidylinositol 3,4,5-trisphosphate-dependent guanine nucleotide exchange factor (GEF) which, independently of RAS, transduces signals from tyrosine kinase receptors to RAC. It also mediates signaling of membrane ruffling. Regulates the actin cytoskeleton as an effector or adapter protein in response to agonist stimulated phosphatidylinositol (3,4)-bisphosphate production and cell protrusion.
Subcellular Location:
Cytoplasm. Cell membrane. Nucleus. Cell projection > lamellipodium. In resting B-cells it is localized mainly in the cytoplasm and upon cell activation it is recruited to the plasma membrane and then translocates to the nucleus. In activated, class-switching B-cells it is associated with membrane IgG but not IgM. Localized to loose actin filament arrays located behind actively extending lamellipodia.
Tissue Specificity:
Expressed only in mature B-cells including those associated with mucosa-associated tissue and bronchus-associated tissue (PubMed:10681448). Widely expressed. Abundant in spleen, and fairly abundant in kidney, lung and liver. Also found in monocytes and macrophages (PubMed:12925760).
Post-translational modifications:
Tyrosine-phosphorylated.
Similarity:
Contains 1 PH domain.
Database links:
Entrez Gene: 23075 Human
Entrez Gene: 20947 Mouse
Entrez Gene: 293410 Rat
Omim: 604762 Human
SwissProt: Q5F4B2 Chicken
SwissProt: P0C1G6 Cow
SwissProt: Q9UH65 Human
SwissProt: Q6A028 Mouse
Unigene: 153026 Human
Unigene: 334144 Mouse
Unigene: 92644 Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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