Function:
Probable transcriptional regulator involved in developmental processes. May act as a transcriptional repressor.
Subunit:
Interacts (via homeobox domain) with APBB1 (via PID domain 1).
Subcellular Location:
Nucleus.
Tissue Specificity:
Expressed in brain; strongly reduced in post-mortem elderly subjects with Alzheimer disease.
Post-translational modifications:
Sumoylated.
Similarity:
Belongs to the teashirt C2H2-type zinc-finger protein family.
Contains 5 C2H2-type zinc fingers.
Contains 1 homeobox DNA-binding domain.
Database links:
Entrez Gene: 128553 Human
Entrez Gene: 228911 Mouse
Omim: 614118 Human
SwissProt: Q9NRE2 Human
SwissProt: Q68FE9 Mouse
Unigene: 473117 Human
Unigene: 315789 Mouse
Unigene: 468546 Mouse
Unigene: 482636 Mouse
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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