background:
The WNT gene family consists of structurally related genes which encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene is a member of the WNT gene family. It encodes a protein which shows 94% and 80% amino acid identity to the mouse Wnt5b protein and the human WNT5A protein, respectively. Alternative splicing of this gene generates 2 transcript variants. [provided by RefSeq, Jul 2008]
Function:
Ligand for members of the frizzled family of seven transmembrane receptors. Probable developmental protein. May be a signaling molecule which affects the development of discrete regions of tissues. Is likely to signal over only few cell diameters.
Subunit:
Interacts with PORCN.
Subcellular Location:
Secreted > extracellular space > extracellular matrix.
Similarity:
Belongs to the Wnt family.
Database links:
Entrez Gene: 508008 Cow
Entrez Gene: 486756 Dog
Entrez Gene: 81029 Human
Entrez Gene: 22419 Mouse
Entrez Gene: 100349579 Rabbit
Entrez Gene: 282582 Rat
Entrez Gene: 30105 Zebrafish
Omim: 606361 Human
SwissProt: Q9H1J7 Human
SwissProt: P22726 Mouse
SwissProt: Q92050 Zebrafish
Unigene: 306051 Human
Unigene: 321818 Mouse
Unigene: 58724 Rat
Unigene: 389 Zebrafish
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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