Rabbit Anti-COUP-TF1/FITC Conjugated antibody

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Chicken ovalbumin upstream promoter 1; chicken ovalbumin upstream promoter; COT1_HUMAN; COUP transcription factor 1; COUP transcription factor I; COUP-TF I; COUP TF1; EAR-3; EAR3; ERBAL3; NR2F1; Nuclear receptor subfamily 2 group F member 1; SVP44; TCFCOU

Cat:

SL20421R-FITC

Species Reactivity：

Rat,(predicted: Human,Mouse,Pig,Cow,Sheep,)

Immunogen：

KLH conjugated synthetic peptide derived from human COUP-TF1

Format：

Lyophilized or Liquid

Storage instructions：

Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of ant

Buffer：

0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

Concentration：

1mg/ml

Clonality：

Polyclonal

Isotype：

IgG

Applications：

ICC=1:50-200IF=1:50-200not yet tested in other applications.optimal dilutions/concentrations should be determined by the end user.

Host：

Rabbit

Calculated MW：

46kDa

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Unit:

Price: $596.00

Product PDFs

Datasheet: Down Datasheet

Other Information
Citations
Protein Attributes
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background:
COUP transcription factors have been cloned in several species and identified as orphan members of the steroid/thyroid hormone receptor superfamily. COUP-TFI (also designated COUP or EAR-3) and ARP-1 (also designated COUP-TFII) exhibit highly regulated and overlapping expression in most tissues. COUP-TFs are highly expressed in the developing and central nervous system, suggesting that these factors may be important in neural development and differentiation. COUP-TFs can compete for binding to response elements which are common to other members of this family, including RAR, RXR, PPAR, HNF-4, VDR and TR. They have been shown to act as negative regulators as well as initiators of transcription.

Function:
Coup (chicken ovalbumin upstream promoter) transcription factor binds to the ovalbumin promoter and, in conjunction with another protein (S300-II) stimulates initiation of transcription. Binds to both direct repeats and palindromes of the 5'-AGGTCA-3' motif. Represses transcriptional activity of LHCG.

Subunit:
Binds DNA as dimer; homodimer and probable heterodimer with NR2F6. Interacts with COPS2.

Subcellular Location:
Nucleus.

Similarity:
Belongs to the nuclear hormone receptor family. NR2 subfamily.
Contains 1 nuclear receptor DNA-binding domain.

Database links:

Entrez Gene: 7025 Human

Entrez Gene: 13865 Mouse

Entrez Gene: 8368 Rat

Omim: 132890 Human

SwissProt: P10589 Human

SwissProt: Q60632 Mouse

Unigene: 519445 Human

Unigene: 439653 Mouse

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

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