Rabbit Anti-PTPN18/FITC Conjugated antibody

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BDP 1; Brain derived phosphatase; Brain-derived phosphatase; Protein tyrosine phosphatase non receptor type 18; Protein tyrosine phosphatase non receptor type 18 brain derived; PTN18_HUMAN; PTP HSCF; PTPN 18; PTPN18; Tyrosine protein phosphatase

Cat:

SL4430R-FITC

Species Reactivity：

Mouse,(predicted: Human,Rat,Pig,Cow,Horse,)

Immunogen：

KLH conjugated synthetic peptide derived from human PTPN18

Format：

Lyophilized or Liquid

Storage instructions：

Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of ant

Buffer：

0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

Concentration：

1mg/ml

Clonality：

Polyclonal

Isotype：

IgG

Applications：

ICC=1:50-200IF=1:50-200not yet tested in other applications.optimal dilutions/concentrations should be determined by the end user.

Host：

Rabbit

Calculated MW：

50kDa

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Unit:

Price: $596.00

Product PDFs

Datasheet: Down Datasheet

Other Information
Citations
Protein Attributes
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background:
The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, the mitotic cycle, and oncogenic transformation. This PTP contains a PEST motif, which often serves as a protein-protein interaction domain, and may be related to protein intracellular half-live. This protein can differentially dephosphorylate autophosphorylated tyrosine kinases that are overexpressed in tumor tissues, and it appears to regulate HER2, a member of the epidermal growth factor receptor family of receptor tyrosine kinases. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2008]

Function:
Differentially dephosphorylate autophosphorylated tyrosine kinases which are known to be overexpressed in tumor tissues.

Subcellular Location:
Nucleus. Cytoplasm.

Tissue Specificity:
Expressed in brain, colon and several tumor-derived cell lines.

Similarity:
Belongs to the protein-tyrosine phosphatase family. Non-receptor class 4 subfamily. Contains 1 tyrosine-protein phosphatase domain.

Database links:

Entrez Gene: 26469 Human

Omim: 606587 Human

SwissProt: Q99952 Human

Unigene: 516390 Human

Unigene: 726000 Human

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

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