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Rabbit Anti-PRMT2/FITC Conjugated antibody
Function:
Arginine methyltransferase that methylates the guanidino nitrogens of arginyl residues in proteins such as STAT3, FBL, histone H4. Acts as a coactivator (with NCOA2) of the androgen receptor (AR)-mediated transactivation. Acts as a coactivator (with estrogen) of estrogen receptor (ER)-mediated transactivation. Enhances PGR, PPARG, RARA-mediated transactivation. May inhibit NF-kappa-B transcription and promote apoptosis. Represses E2F1 transcriptional activity (in a RB1-dependent manner). May be involved in growth regulation.
Subunit:
Self-associates. Interacts with RB1 and E2F1 (By similarity). Interacts with NCOA6 coactivator. Interacts (via SH3 domain) with PRMT8. Interacts with AR. Interacts with NFKBIA.Interacts with ESR1, ESR2, PGR, PPARG, RARA, RXRA and THRB.Interacts with HNRNPUL1.
Subcellular Location:
Cytoplasm. Nucleus. Translocates from the cytoplasm to the nucleus, after hormone exposure.
Tissue Specificity:
Widely expressed. Highly expressed in androgen target organs such as heart, prostate, skeletal muscle, ovary and spinal cord.
Similarity:
Belongs to the protein arginine N-methyltransferase family.
Contains 1 SH3 domain.
Database links:
Entrez Gene: 3275 Human
Entrez Gene: 15468 Mouse
Entrez Gene: 499420 Rat
Omim: 601961 Human
SwissProt: P55345 Human
SwissProt: Q9R144 Mouse
Unigene: 154163 Human
Unigene: 6420 Mouse
Unigene: 145566 Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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