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Rabbit Anti-PURB/FITC Conjugated antibody
background:
This gene product is a sequence-specific, single-stranded DNA-binding protein. It binds preferentially to the single strand of the purine-rich element termed PUR, which is present at origins of replication and in gene flanking regions in a variety of eukaryotes from yeasts through humans. Thus, it is implicated in the control of both DNA replication and transcription. Deletion of this gene has been associated with myelodysplastic syndrome and acute myelogenous leukemia. [provided by RefSeq, Jul 2008]
Function:
Has capacity to bind repeated elements in single-stranded DNA such as the purine-rich single strand of the PUR element located upstream of the MYC gene. Plays a role in the control of vascular smooth muscle (VSM) alpha-actin gene transcription as repressor in myoblasts and fibroblasts. Participates in transcriptional and translational regulation of alpha-MHC expression in cardiac myocytes by binding to the purine-rich negative regulatory (PNR) element. Modulates constitutive liver galectin-3 gene transcription by binding to its promoter. May play a role in the dendritic transport of a subset of mRNAs.
Subunit:
Homodimer, heterodimer with PURA and heterotrimer with PURA and YBX1/Y-box protein 1.
Subcellular Location:
Nucleus.
Tissue Specificity:
Expressed in myocardium of heart failure patients.
Post-translational modifications:
Phosphorylated upon DNA damage, probably by ATM or ATR.
Similarity:
Belongs to the PUR DNA-binding protein family.
Database links:
Entrez Gene: 5814 Human
Entrez Gene: 19291 Mouse
Entrez Gene: 491687 Rat
Omim: 608887 Human
SwissProt: Q96QR8 Human
SwissProt: O35295 Mouse
SwissProt: Q68A21 Rat
Unigene: 349150 Human
Unigene: 596321 Human
Unigene: 728785 Human
Unigene: 296150 Mouse
Unigene: 390332 Mouse
Unigene: 156213 Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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