Rabbit Anti-CD96/FITC Conjugated antibody

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CD96; Cell surface antigen CD96; DKFZp667E2122; MGC22596; T cell activated increased late expression protein; T cell surface protein tactile precursor; T cell-activated increased late expression protein; T-cell surface protein tactile; TACT_HUMAN;

Cat:

SL20268R-FITC

Immunogen：

KLH conjugated synthetic peptide derived from human CD96

Format：

Lyophilized or Liquid

Storage instructions：

Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of ant

Buffer：

0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

Concentration：

1mg/ml

Clonality：

Polyclonal

Isotype：

IgG

Applications：

ICC=1:50-200IF=1:50-200not yet tested in other applications.optimal dilutions/concentrations should be determined by the end user.

Host：

Rabbit

Calculated MW：

298kDa

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Unit:

Price: $596.00

Product PDFs

Datasheet: Down Datasheet

Other Information
Citations
Protein Attributes
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background:
CD96 antigen, also designated T cell surface protein tactile (T cell activation, increased late expression) precursor, is a type I membrane protein and is a member of the immunoglobulin supergene family of proteins. The gene encoding for the CD96 protein maps to chromosome 3q13.13-q13.2. During the late phases of the immune response, CD96 is involved in adhesive interactions of activated, both helper and cytotoxic, NK and T cells. It interacts with CD155. CD96, shows increased expression after NK and T cell activation. It can also be found actively engaging diseased cells and moving in inflamed areas after NK and T cells have moved through the endothelium. CD96 is involved in antigen presentation and/or lymphocyte activation. The protein, which may form a homodimer, is expressed on normal T cell lines and some transformed T cells.

Function:
May be involved in adhesive interactions of activated T and NK cells during the late phase of the immune response. Promotes NK cell-target adhesion by interacting with PVR present on target cells. May function at a time after T and NK cells have penetrated the endothelium using integrins and selectins, when they are actively engaging diseased cells and moving within areas of inflammation.

Subunit:
Homodimer; disulfide-linked. Interacts with PVR.

Subcellular Location:
Membrane; Single-pass type I membrane protein.

Tissue Specificity:
Expressed on normal T-cell lines and clones, and some transformed T-cells, but no other cultured cell lines tested. It is expressed at very low levels on activated B-cells.

DISEASE:
C syndrome (CSYN) [MIM:211750]: A syndrome characterized by trigonocephaly, severe mental retardation, hypotonia, variable cardiac defects, redundant skin, and dysmorphic facial features, including upslanted palpebral fissures, epicanthal folds, depressed nasal bridge, and low-set, posteriorly rotated ears. {ECO:0000269|PubMed:17847009}. Note=The disease is caused by mutations affecting the gene represented in this entry. A chromosomal aberration involving CD96 has been found in a patient with C syndrome. Translocation t(3;18)(q13.13;q12.1). CD96 gene was located at the 3q13.13 breakpoint. Precise structural analysis around the breakpoint showed that the gene was disrupted by the translocation in exon 5, probably leading to premature termination or loss of expression of CD96 protein. No gene was detected at the chromosome 18 breakpoint.

Similarity:
Contains 1 Ig-like C2-type (immunoglobulin-like) domain.
Contains 2 Ig-like SLVtype (immunoglobulin-like) domains.

Database links:

Entrez Gene: 10225 Human

Omim: 606037 Human

SwissProt: P40200 Human

Unigene: 142023 Human

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

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