background:
This gene encodes a GTPase-activating protein that activates the small guanine-nucleotide-binding protein Rap1 in platelets. The protein interacts with synaptotagmin-like protein 1 and Rab27 and regulates secretion of dense granules from platelets at sites of endothelial damage. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2009]
Tissue Specificity:
Cytoplasmic; perinuclear region.
Similarity:
Contains 1 RanBD1 domain.
Database links:
Entrez Gene: 23108 Human
Entrez Gene: 380711 Mouse
SwissProt: Q684P5 Human
SwissProt: Q5SVL6 Mouse
Unigene: 499659 Human
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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