background:
Organic ion transporters, such as SLC22A15, transport various medically and physiologically important compounds, including pharmaceuticals, toxins, hormones, neurotransmitters, and cellular metabolites. These transporters are also referred to as amphiphilic solute facilitators (ASFs).[supplied by OMIM, Apr 2004]
Function:
Probably transports organic cations (By similarity). Appears not to be the agmatine transporter.
Subcellular Location:
Membrane.
Tissue Specificity:
Expressed at highest levels in kidney and brain. Expressed at high levels in skeletal muscle, heart, liver, placenta and white blood cells. Expressed at moderate levels in lung and spleen. Expressed at low levels in thymus, small intestine and colon. Expressed in several intestinal tumor cell lines.
Similarity:
Belongs to the major facilitator superfamily. Organic cation transporter family.
Database links:
Entrez Gene: 55356 Human
Entrez Gene: 242126 Mouse
Entrez Gene: 310732 Rat
Omim: 608275 Human
SwissProt: Q8IZD6 Human
SwissProt: Q504N2 Mouse
Unigene: 125482 Human
Unigene: 90204 Mouse
Unigene: 46389 Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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