Rabbit Anti-PRPF4/FITC Conjugated antibody

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HPRP4; HPRP4P; PRP4; PRP4 pre mRNA processing factor 4 homolog (yeast); PRP4/STK/WD splicing factor; Prp4p; U4/U6 small nuclear ribonucleoprotein Prp4; WD splicing factor Prp4; PRP4_HUMAN.

Cat:

SL20098R-FITC

Species Reactivity：

Mouse,(predicted: Human,Rat,Dog,Pig,Cow,Rabbit,Sheep,)

Immunogen：

KLH conjugated synthetic peptide derived from human PRPF4

Format：

Lyophilized or Liquid

Storage instructions：

Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of ant

Buffer：

0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

Concentration：

1mg/ml

Clonality：

Polyclonal

Isotype：

IgG

Applications：

ICC=1:50-200IF=1:50-200not yet tested in other applications.optimal dilutions/concentrations should be determined by the end user.

Host：

Rabbit

Calculated MW：

58kDa

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Unit:

Price: $596.00

Product PDFs

Datasheet: Down Datasheet

Other Information
Citations
Protein Attributes
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background:
Pre-mRNA splicing occurs in two sequential transesterification steps, and the protein encoded by this gene is thought to be involved in pre-mRNA splicing and in signal transduction. This protein belongs to a kinase family that includes serine/arginine-rich protein-specific kinases and cyclin-dependent kinases (CDKs). This protein is regarded as a CDK-like kinase (Clk) with homology to mitogen-activated protein kinases (MAPKs). [provided by RefSeq, Jul 2008]

Function:
Involved in pre-mRNA splicing.

Subunit:
Interacts directly with PRPF18, PPIH and PRPF3. Part of a heteromeric complex containing PPIH, PRPF3 and PRPF4 that is stable in the absence of RNA. This complex interacts with the U4/U5/U6 tri-snRNP complex.

Subcellular Location:
Nucleus speckle. Note=Colocalizes with spliceosomal snRNPs.

Similarity:
Contains 7 WD repeats.

Database links:

Entrez Gene: 8899 Human

Entrez Gene: 19134 Mouse

Entrez Gene: 291078 Rat

Omim: 602338 Human

SwissProt: Q08DZ2 Cow

SwissProt: Q13523 Human

SwissProt: Q61136 Mouse

SwissProt: Q5RKH1 Rat

Unigene: 159014 Human

Unigene: 10027 Mouse

Unigene: 482253 Mouse

Unigene: 32654 Rat

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

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