background:
Quinolinate phosphoribosyltransferase (QPRTase) is a major enzyme in the catabolism of quinolinate. Quinolinate is an intermediate in the tryptophan-nicotinamide adenine dinucleotide (NAD) pathway, leading to the production of nicotinic acid, carbon dioxide, and pyrophosphate. Catabolism of quinolinate is vital due to the quinolinate’s neurotoxicity. Increased levels of quinolinate have been linked to neurodegenerative symptoms associated with meningitis and AIDS. QAPRTase has a seven-stranded alpha/beta-barrel domain which is similar in structure to the eight-stranded alpha/beta-barrel enzymes. The protein possesses a novel fold in comparison to other members of the PRTase family. This fold comprises a structure combining two domains. The structure is part alpha/beta barrel-like domain, and part alpha/beta N-terminal domain.
Function:
Involved in the catabolism of quinolinic acid (QA).
Subunit:
Hexamer formed by 3 homodimers.
Similarity:
Belongs to the nadC/modD family.
Database links:
Entrez Gene: 614254 Cow
Entrez Gene: 607664 Dog
Entrez Gene: 100727900 Guinea pig
Entrez Gene: 100065768 Horse
Entrez Gene: 23475 Human
Entrez Gene: 100406642 Marmoset (common)
Omim: 606248 Human
SwissProt: Q3T063 Cow
SwissProt: Q15274 Human
Unigene: 513484 Human
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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