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Rabbit Anti-CES2/FITC Conjugated antibody
background:
This gene encodes a member of the carboxylesterase large family. The family members are responsible for the hydrolysis or transesterification of various xenobiotics, such as cocaine and heroin, and endogenous substrates with ester, thioester, or amide bonds. They may participate in fatty acyl and cholesterol ester metabolism, and may play a role in the blood-brain barrier system. The protein encoded by this gene is the major intestinal enzyme and functions in intestine drug clearance. Alternatively spliced transcript variants have been found for this gene.[provided by RefSeq, Oct 2010]
Function:
Involved in the detoxification of xenobiotics and in the activation of ester and amide prodrugs. Shows high catalytic efficiency for hydrolysis of cocaine, 4-methyumbelliferyl acetate, heroin and 6-monoacetylmorphine.
Subcellular Location:
Endoplasmic reticulum lumen.
Tissue Specificity:
Preferentially expressed in intestine with moderate expression in liver. Within the intestine, highest expression is found in small intestine with lower expression in colon and rectum.
Post-translational modifications:
Glycosylated.
Similarity:
Belongs to the type-B carboxylesterase/lipase family.
Database links:
Entrez Gene: 8824 Human
Omim: 605278 Human
SwissProt: O00748 Human
Unigene: 282975 Human
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
羧酸酯酶主要位于肝、其他组织及细胞胞液、线粒体和内质网。 是一种多聚蛋白，主要催化酯、硫酸酯和酰胺的水解。
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