Rabbit Anti-TIPRL/FITC Conjugated antibody

Home > Product > Antibody > Rabbit Anti-TIPRL/FITC Conjugated antibody

1810011K17Rik; dJ69E11.3; MGC3794; Putative MAPK activating protein PM10; Putative MAPK-activating protein PM10; RP1-69E11.1; Tip; TIP41; TIP41-like protein; tiprl; TIPRL_HUMAN; TOR Signaling Pathway Regulator like; Type 2A-interacting protein

Cat:

SL19121R-FITC

Species Reactivity：

Mouse,(predicted: Human,Rat,Dog,Pig,Cow,Horse,Rabbit,Guinea Pig,)

Immunogen：

KLH conjugated synthetic peptide derived from human TIPRL

Format：

Lyophilized or Liquid

Storage instructions：

Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of ant

Buffer：

0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

Concentration：

1mg/ml

Clonality：

Polyclonal

Isotype：

IgG

Applications：

ICC=1:50-200IF=1:50-200not yet tested in other applications.optimal dilutions/concentrations should be determined by the end user.

Host：

Rabbit

Calculated MW：

31kDa

prev next

Unit:

Price: $596.00

Product PDFs

Datasheet: Down Datasheet

Other Information
Citations
Protein Attributes
Feedback Wall

background:
TIPRL is an inhibitory regulator of protein phosphatase-2A (PP2A) (see PPP2CA; MIM 176915), PP4 (see PPP4C; MIM 602035), and PP6 (see PPP6C; MIM 612725) (McConnell et al., 2007 [PubMed 17384681]).[supplied by OMIM, Nov 2010]

Function:
May be a allosteric regulator of serine/threonine-protein phosphatase 2A (PP2A). Isoform 1 inhibits catalytic activity of the PP2A(D) core complex in vitro. The PP2A(C):TIPRL complex does not show phosphatase activity. May play a role in the regulation of ATM/ATR signaling pathway controlling DNA replication and repair.

Subunit:
Isoform 1 interacts with PPP2CA. Isoform 2 does notinteract with PPP2CA. Interacts with PPP2CB, PPP4C and PPP6C.Interacts with IGBP1; the interaction is dependent on PPP2CA.Associates with a protein phosphatase 2A PP2A(C):alpha-4 complex.

Subcellular Location:
Cytoplasm.

Similarity:
Belongs to the TIP41 family.

Database links:

Entrez Gene: 261726 Human

Entrez Gene: 226591 Mouse

Entrez Gene: 72869 Rat

Omim: 62367 Human

SwissProt: O75663 Human

SwissProt: Q8SH58 Mouse

SwissProt: A2VCX1 Rat

Unigene: 209431 Human

Unigene: 21520 Mouse

Unigene: 56867 Rat

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

Product Feedback Wall