Home
>
Product
>
Antibody
>
Rabbit Anti-DUSP6/FITC Conjugated antibody
background:
The protein encoded by this gene is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which are associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene product inactivates ERK2, is expressed in a variety of tissues with the highest levels in heart and pancreas, and unlike most other members of this family, is localized in the cytoplasm. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Function:
Inactivates MAP kinases. Has a specificity for the ERK family.
Subcellular Location:
Cytoplasm.
Similarity:
Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.
Contains 1 rhodanese domain.
Contains 1 tyrosine-protein phosphatase domain.
Database links:
Entrez Gene: 1848 Human
Entrez Gene: 67603 Mouse
Entrez Gene: 116663 Rat
Omim: 602748 Human
SwissProt: Q16828 Human
SwissProt: Q9DBB1 Mouse
SwissProt: Q64346 Rat
Unigene: 298654 Human
Unigene: 1791 Mouse
Unigene: 4313 Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
|
|