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Rabbit Anti-RBM19/FITC Conjugated antibody
background:
This gene encodes a nucleolar protein that contains six RNA-binding motifs. The encoded protein may be involved in regulating ribosome biogenesis. Multiple alternatively spliced variants, encoding the same protein, have been identified.[provided by RefSeq, Apr 2009]
Function:
Plays a role in embryo pre-implantation development.
Subcellular Location:
Nucleus > nucleolus. Nucleus > nucleoplasm. Cytoplasm. Chromosome. In discrete foci distributed throughout the cytoplasm and nucleoplasm during the 4 to 8 cell stages and the morula stage, but not in the periphery of the nucleolar precursor body (NPB). During blastocyst development, becomes increasingly localized to the nucleolus and less to the cytoplasm. At the late blastocyst stage, localized predominantly in the nucleolus. Localized in the nucleolus during interphase and to the perichromosomal sheath during mitosis. Does not colocalize in the cytoplasm with GW182 in P-bodies. May translocate to the nucleolus upon early embryonic development (By similarity). Colocalizes with NPM1 during interphase. By late prophase, metaphase, anaphase and telophase, associates with the chromosome periphery. By telophase localizes to NPB.
Tissue Specificity:
Expressed in the crypts of Lieberkuhn of the intestine and in intestinal neoplasia (at protein level).
Similarity:
Belongs to the RRM MRD1 family.
Contains 6 RRM (RNA recognition motif) domains.
Database links:
Entrez Gene: 9904 Human
Entrez Gene: 74111 Mouse
Entrez Gene: 304512 Rat
SwissProt: Q9Y4C8 Human
SwissProt: Q8R3C6 Mouse
Unigene: 7482 Human
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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