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Rabbit Anti-LDL receptor/FITC Conjugated antibody
background:
The low density lipoprotein receptor (LDLR) gene family consists of cell surface proteins involved in receptor-mediated endocytosis of specific ligands. Low density lipoprotein (LDL) is normally bound at the cell membrane and taken into the cell ending up in lysosomes where the protein is degraded and the cholesterol is made available for repression of microsomal enzyme 3-hydroxy-3-methylglutaryl coenzyme A (HMG CoA) reductase, the rate-limiting step in cholesterol synthesis. At the same time, a reciprocal stimulation of cholesterol ester synthesis takes place. Mutations in this gene cause the autosomal dominant disorder, familial hypercholesterolemia.
Function:
Binds LDL, the major cholesterol-carrying lipoprotein of plasma, and transports it into cells by endocytosis. In order to be internalized, the receptor-ligand complexes must first cluster into clathrin-coated pits. In case of HISLV1 infection, functions as a receptor for extracellular Tat in neurons, mediating its internalization in uninfected cells.
Subunit:
Interacts with LDLRAP1. Interacts with SNX17. Interacts with HCV E1/E2 heterodimer. Interacts with HISLV1 Tat.
Subcellular Location:
Cell membrane; Single-pass type I membrane protein. Endomembrane system; Single-pass type I membrane protein. Membrane, clathrin-coated pit; Single-pass type I membrane protein. Note=Found distributed from the plasma membrane to intracellular compartments.
Tissue Specificity:
Binds LDL, the major cholesterol-carrying lipoprotein of plasma, and transports it into cells by endocytosis. In order to be internalized, the receptor-ligand complexes must first cluster into clathrin-coated pits. In case of HISLV1 infection, functions as a receptor for extracellular Tat in neurons, mediating its internalization in uninfected cells.
Post-translational modifications:
N- and O-glycosylated.
Ubiquitinated by MYLIP leading to degradation.
Similarity:
Belongs to the LDLR family.
Contains 3 EGF-like domains.
Contains 7 LDL-receptor class A domains.
Contains 6 LDL-receptor class B repeats.
Database links:
Entrez Gene: 3949 Human
Entrez Gene: 16835 Mouse
Entrez Gene: 300438 Rat
Omim: 606945 Human
SwissProt: P01130 Human
SwissProt: P35951 Mouse
SwissProt: P35952 Rat
Unigene: 213289 Human
Unigene: 728190 Human
Unigene: 3213 Mouse
Unigene: 10483 Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
低密度脂蛋白受体 LDLR是一种存在于细胞表面的、可识别多种配体的脂蛋白受体，在体内对于富含甘油三酯的脂蛋白代谢非常重要;
LDL R目前主要用于代谢及肿瘤方面的研究。
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