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Rabbit Anti-Involucrin/FITC Conjugated antibody
background:
Involucrin, a component of the keratinocyte crosslinked envelope, is found in the cytoplasm and crosslinked to membrane proteins by transglutaminase. This gene is mapped to 1q21, among calpactin I light chain, trichohyalin, profillaggrin, loricrin, and calcyclin. [provided by RefSeq, Jul 2008].
Function:
Part of the insoluble cornified cell envelope (CE) of stratified squamous epithelia.
Subunit:
Directly or indirectly cross-linked to cornifelin (CNFN).
Subcellular Location:
Cytoplasm.
Tissue Specificity:
Keratinocytes of epidermis and other stratified squamous epithelia.
Post-translational modifications:
Substrate of transglutaminase. Some glutamines and lysines are cross-linked to other involucrin molecules, to other proteins such as keratin, desmoplakin, periplakin and envoplakin, and to lipids like omega-hydroxyceramide.
Similarity:
Belongs to the involucrin family.
Database links:
Entrez Gene: 3713 Human
Entrez Gene: 16447 Mouse
Entrez Gene: 60583 Rat
Omim: 14772 Human
SwissProt: P07476 Human
SwissProt: P48997 Mouse
SwissProt: P48998 Rat
Unigene: 516439 Human
Unigene: 207365 Mouse
Unigene: 142591 Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
套膜蛋白又称内披蛋白或囊包蛋白,与毛透明蛋白共同构成角质细胞包膜支架的蛋白质。在角质细胞分化时,首先出现在表皮棘层的上层细胞中的标志性蛋白质,该蛋白在角质细胞和其他复层扁平上皮合成的蛋白。最初存在于细胞质中,然后通过转谷氨酰胺酶的作用,转变为交联的膜蛋白。
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