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Rabbit Anti-Nurr1/FITC Conjugated antibody
background:
Nuclear receptor and transcription factor; plays a role in development and maintenance of neurons synthesizing the neurotransmitter dopamine This gene encodes a member of the steroid-thyroid hormone-retinoid receptor superfamily. The encoded protein may act as a transcription factor. Mutations in this gene have been associated with disorders related to dopaminergic dysfunction, including Parkinson disease, schizophernia, and manic depression. Misregulation of this gene may be associated with rheumatoid arthritis. Four transcript variants encoding four distinct isoforms have been identified for this gene. Additional alternate splice variants may exist, but their full length nature has not been determined.
Function:
Transcriptional regulator which is important for the differentiation and maintenance of meso-diencephalic dopaminergic (mdDA) neurons during development. It is crucial for expression of a set of genes such as SLC6A3, SLC18A2, TH and DRD2 which are essential for development of mdDA neurons.
Subunit:
Interacts with SFPQ, NCOR2, SIN3A and HADC1. The interaction with NCOR2 increases in the absence of PITX3 (By similarity).
Subcellular Location:
Nucleus.
Tissue Specificity:
Expressed in a number of cell lines of T-cell, B-cell and fibroblast origin. Strong expression in brain tissue.
Similarity:
Belongs to the nuclear hormone receptor family. NR4 subfamily.
Contains 1 nuclear receptor DNA-binding domain.
Database links:
Entrez Gene: 4929 Human
Entrez Gene: 18227 Mouse
Entrez Gene: 54278 Rat
Omim: 601828 Human
SwissProt: P43354 Human
SwissProt: Q06219 Mouse
SwissProt: Q07917 Rat
Unigene: 563344 Human
Unigene: 3507 Mouse
Unigene: 88129 Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
该抗体和类固醇/甲状腺素受体密切相关的早期应急反应基因,也受各种生长因子的诱导。中脑多巴胺神经细胞和脑干细胞表达。
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