Home
>
Product
>
Antibody
>
Rabbit Anti-Wnt3a/FITC Conjugated antibody
background:
The WNT gene family consists of structurally related genes which encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene is a member of the WNT gene family. It encodes a protein which shows 96% amino acid identity to mouse Wnt3A protein, and 84% to human WNT3 protein, another WNT gene product. This gene is clustered with WNT14 gene, another family member, in chromosome 1q42 region. [provided by RefSeq, Jul 2008]
Function:
Ligand for members of the frizzled family of seven transmembrane receptors. Wnt-3 and Wnt-3a play distinct roles in cell-cell signaling during morphogenesis of the developing neural tube.
Subunit:
Interacts with PORCN. Interacts with APCDD1 and WLS. Component of the Wnt-Fzd-LRP5-LRP6 signaling complex that contains a WNT protein, a FZD protein and LRP5 or LRP6. Interacts directly in the complex with LRP6.
Subcellular Location:
Secreted, extracellular space, extracellular matr
Tissue Specificity:
Moderately expressed in placenta and at low levels in adult lung, spleen, and prostate.
Post-translational modifications:
Palmitoylation at Ser-209 by PORCN is required for proper trafficking to cell surface, vacuolar acidification is critical to release palmitoylated WNT3A from WLS in secretory vesicles.
Similarity:
Belongs to the Wnt family.
Database links:
Entrez Gene: 89780 Human
Entrez Gene: 22416 Mouse
Entrez Gene: 303181 Rat
Omim: 606359 Human
SwissProt: P56704 Human
SwissProt: P27467 Mouse
Unigene: 336930 Human
Unigene: 1367 Mouse
Unigene: 130971 Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
Wnt3a是Wnt家族的成员之一,对神经干细胞的增殖及分化有一定的调控作用,Wnt3a蛋白可以促进神经干细胞向神经元分化.
|
|
