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Rabbit Anti-Myoglobin/FITC Conjugated antibody
background:
Myoglobin is a small heme containing protein responsible for the oxygen deposition in muscle tissues. Only one form of myoglobin is expressed in cardiac and skeletal muscles. Myoglobin is known as a marker of myocardial damage and it has been used for more than three decades. Nowadays it still is very commonly used in clinical practice as an early marker of AMI. It appears in patient's blood 1 to 3 hours after onset of the symptoms, reaching peak level within 8 to 12 hours. Myoglobin is not so cardiac specific as cTnI or cTnT. Because of high myoglobin concentration in skeletal muscle tissue, even minor skeletal muscle injury results in the significant increase of myoglobin concentration in blood. Thus myoglobin is used together with cTnI or cTnT in clinical practise for better specificity in AMI diagnosis.
Function:
Serves as a reserve supply of oxygen and facilitates the movement of oxygen within muscles.
Similarity:
Belongs to the globin family.
Database links:
Entrez Gene: 4151 Human
Entrez Gene: 17189 Mouse
Entrez Gene: 59108 Rat
Omim: 160000 Human
SwissProt: P02144 Human
SwissProt: P04247 Mouse
SwissProt: Q9QZ76 Rat
Unigene: 517586 Human
Unigene: 404074 Mouse
Unigene: 40511 Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
肌红蛋白存在于肌肉中,心肌中含量特别丰富,,有较高的组织特异性,是横纹肌的特异性标记物,但对肿瘤的敏感性较差。主要用于横纹肌肿瘤的诊断与鉴别诊断。少数恶性中胚叶混合瘤、睾丸畸胎瘤、肾母细胞瘤亦可见阳性表达。
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