Rabbit Anti-phospho-APG4B (Ser34)/FITC Conjugated antibody

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APG4B (phospho-Ser34); APG4B (phospho Ser34); APG4B (phospho S34); APG4B (p-Ser34); p-APG4B (Ser34); APG4B; ATG4 autophagy related 4 homolog B (S. cerevisiae); AUT like 1 cysteine endopeptidase; AUTL1; Autophagin 1; Autophagy related cysteine endopeptidas

Cat:

SL20429R-FITC

Species Reactivity：

Rat,(predicted: Human,Mouse,Pig,)

Immunogen：

KLH conjugated Synthesised phosphopeptide derived from human APG4B around the phosphorylation site of Ser34

Format：

Lyophilized or Liquid

Storage instructions：

Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of ant

Buffer：

0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

Concentration：

1mg/ml

Clonality：

Polyclonal

Isotype：

IgG

Applications：

ICC=1:50-200IF=1:50-200not yet tested in other applications.optimal dilutions/concentrations should be determined by the end user.

Host：

Rabbit

Calculated MW：

44kDa

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Unit:

Price: $596.00

Product PDFs

Datasheet: Down Datasheet

Other Information
Citations
Protein Attributes
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background:
ATG4B is a cysteine protease required for autophagy, which cleaves the SLCterminal part of either MAP1LC3, GABARAPL2 or GABARAP, allowing the liberation of form I. A subpopulation of form I is subsequently converted to a smaller form (form II). Form II, with a revealed SLCterminal glycine, is considered to be the phosphatidylethanolamine (PE)-conjugated form, and has the capacity for the binding to autophagosomes.

Function:
Cysteine protease required for autophagy, which cleaves the SLCterminal part of either MAP1LC3, GABARAPL2 or GABARAP, allowing the liberation of form I. A subpopulation of form I is subsequently converted to a smaller form (form II). Form II, with a revealed SLCterminal glycine, is considered to be the phosphatidylethanolamine (PE)-conjugated form, and has the capacity for the binding to autophagosomes.

Subcellular Location:
Cytoplasm (Probable).

Tissue Specificity:
Mainly expressed in the skeletal muscle, followed by brain, heart, liver and pancreas.

Similarity:
Belongs to the peptidase C54 family.

Database links:

Entrez Gene: 23192 Human

Entrez Gene: 66615 Mouse

Entrez Gene: 316128 Rat

Omim: 611338 Human

SwissProt: Q9Y4P1 Human

SwissProt: Q8BGE6 Mouse

SwissProt: Q62625 Rat

Unigene: 283610 Human

Unigene: 29087 Mouse

Unigene: 163086 Rat

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

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