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Rabbit Anti-ABCG1 /FITC Conjugated antibody
background:
The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the White subfamily. It is involved in macrophage cholesterol and phospholipids transport, and may regulate cellular lipid homeostasis in other cell types. Six alternative splice variants have been identified.
Function:
Transporter involved in macrophage lipid homeostasis. Is an active component of the macrophage lipid export complex. Could also be involved in intracellular lipid transport processes. The role in cellular lipid homeostasis may not be limited to macrophages.
Subunit:
May form heterodimers with several heterologous partners of the ABCG subfamily.
Subcellular Location:
Endoplasmic reticulum membrane. Golgi apparatus membrane. Predominantly localized in the intracellular compartments mainly associated with the endoplasmic reticulum (ER) and Golgi membranes.
Tissue Specificity:
Expressed in several tissues. Expressed in macrophages; expression is increased in macrophages from patients with Tangier disease.
Post-translational modifications:
Palmitoylation at Cys-315 seems important for trafficking from the endoplasmic reticulum.
Similarity:
Belongs to the ABC transporter superfamily. ABCG family. Eye pigment precursor importer (TC 3.A.1.204) subfamily.
Contains 1 ABC transmembrane type-2 domain.
Contains 1 ABC transporter domain.
Database links:
Entrez Gene: 510745 Cow
Entrez Gene: 9619 Human
Entrez Gene: 85264 Rat
Omim: 603076 Human
SwissProt: P45844 Human
Unigene: 124649 Human
Unigene: 8398 Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
ABCG1是ABC转运蛋白家族中的成员,是位于组织浆膜中的单体转运蛋白,多分布于肝、小肠、胎盘、脂肪和脾.主要用于脂质/脂蛋白代谢与动脉粥样硬化方面的研究.
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