Home
>
Product
>
Antibody
>
Rabbit Anti-FGF1/FITC Conjugated antibody
background:
FGF1 also designated Heparin-binding growth factor 1 precursor (HBGF-1) ; Acidic fibroblast growth factor (aFGF). heparin-binding growth factors are angiogenic agents in vivo and are potent mitogens for a variety of cell types in vitro. There are differences in the tissue distribution and concentration of these 2 growth factors. Subunit si monomer.FGF1 belongs to the heparin-binding growth factors family. may play a role in neurite outgrowth; may regulate cell differentiation in the nervous system; may act in synergy with fibronectin to enhance neuronal cell adhesion.
Function:
The heparin-binding fibroblast growth factors play important roles in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. They are potent mitogens in vitro.
Subunit:
Monomer. Homodimer. Interacts with FGFR1, FGFR2, FGFR3 and FGFR4. Affinity between fibroblast growth factors (FGFs) and their receptors is increased by heparan sulfate glycosaminoglycans that function as coreceptors. Found in a complex with FGFBP1, FGF1 and FGF2. Interacts with FGFBP1. Part of a Cu(2+)-dependent multiprotein aggregate containing FGF1, S100A13 and SYT1. Interacts with SYT1. Interacts with S100A13. Interacts with LRRC59. Interacts with CSNKA, CSNKB and FIBP. While binding with LRRC59, CSNKA and FIBP seem mutually exclusive, CSNKB and FIBP may cooperatively interact with FGF1.
Subcellular Location:
Secreted. Cytoplasm. Cytoplasm, cell cortex. Cytoplasm, cytosol. Nucleus. Note=Lacks a cleavable signal sequence. Within the cytoplasm, it is transported to the cell membrane and then secreted by a non-classical pathway that requires Cu(2+) ions and S100A13. Secreted in a complex with SYT1 (By similarity). Binding of exogenous FGF1 to FGFR facilitates endocytosis followed by translocation of FGF1 across endosomal membrane into the cytosol. Nuclear import from the cytosol requires the classical nuclear import machinery, involving proteins KPNA1 and KPNB1, as well as LRRC59.
Tissue Specificity:
Predominantly expressed in kidney and brain. Detected at much lower levels in heart and skeletal muscle.
Post-translational modifications:
In the nucleus, phosphorylated by PKC/PRKCD.
Similarity:
Belongs to the heparin-binding growth factors family.
Database links:
Entrez Gene: 2246 Human
Entrez Gene: 25317 Rat
Entrez Gene: 14164 Mouse
Omim: 131220 Human
SwissProt: P05230 Human
SwissProt: P61149 Rat
SwissProt: P61148 Mouse
Unigene: 483635 Human
Unigene: 17613 Rat
Unigene: 241282 Mouse
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
生长因子和激素（ Growth Factor and Hormones）
肝素结合生长因子(FGF1)可与肝素结合是血管生成剂，还是多种细胞强的促细胞分裂剂，可刺激多种中胚层细胞的生长包括软骨细胞、粒细胞和内皮细胞，在创伤愈合及动物肢体再生中可能起作用。在不同的组织中分布和含量不同，以单体形式存在，属于肝素结合生长因子家族成员之一。
|
|
