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Rabbit Anti-RNF128 /FITC Conjugated antibody
background:
The protein encoded by this gene is a type I transmembrane protein that localizes to the endocytic pathway. This protein contains a RING zinc-finger motif and has been shown to possess E3 ubiquitin ligase activity. Expression of this gene in retrovirally transduced T cell hybridoma significantly inhibits activation-induced IL2 and IL4 cytokine production. Induced expression of this gene was observed in anergic CD4(+) T cells, which suggested a role in the induction of anergic phenotype. Alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008].
Function:
E3 ubiquitin-protein ligase that catalyzes polyubiquitin chains. Functions as an inhibitor of cytokine gene transcription. Inhibits IL2 and IL4 transcription and this activity is likely to be mediated by E3 ligase activity. Plays an important role in the induction of the anergic phenotype. Functions in the patterning of the dorsal ectoderm; sensitizes ectoderm to respond to neural-inducing signals.
Subcellular Location:
Endomembrane system; Single-pass membrane protein. Cytoplasm, perinuclear region. Note=Localized in an asymmetric perinuclear punctuate manner. Localizes to the internal pool of the transferrin recycling endosomal pathway. Partially colocalized with the endoplasmic reticulum resident HSPA5, with Golgi resident STX5, and with the late endosomal GTPase RAB7A.
Post-translational modifications:
Auto-ubiquitinated. Controls the development of T-cell clonal anergy by ubiquitination.
Similarity:
Contains 1 PA (protease associated) domain.
Contains 1 RING-type zinc finger.
Database links:
Entrez Gene: 79589 Human
Entrez Gene: 66889 Mouse
Entrez Gene: 315911 Rat
Omim: 300439 Human
SwissProt: Q8TEB7 Human
SwissProt: Q9D304 Mouse
Unigene: 496542 Human
Unigene: 27764 Mouse
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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