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Rabbit Anti-NCR1/FITC Conjugated antibody
background:
The natural cytotoxicity receptors (NCRs) are a recently characterized family of Ig-like activation receptors that appear to be major triggering receptors in tumor cell recognition. NCR1 is a glycoprotein that has two extracellular Ig-like domains followed by a ~40 amino acid residue stalk region, a type I transmembrane domain, and a short cytoplasmic tail. NCR1 has been shown to represent a novel NK cell-specific molecule involved in human NK cell activation. NCR1 has been implicated in NK cell-mediated lysis of several autologous tumor cells and pathogen-infected cell lines.
Function:
Cytotoxicity-activating receptor that may contribute to the increased efficiency of activated natural killer (NK) cells to mediate tumor cell lysis.
Subunit:
Interacts with CD247 and FCER1G.
Subcellular Location:
Cell membrane; Single-pass type I membrane protein.
Tissue Specificity:
Selectively expressed by both resting and activated NK cells.
Similarity:
Belongs to the natural cytotoxicity receptor (NCR) family.
Contains 2 Ig-like (immunoglobulin-like) domains.
Database links:
Entrez Gene: 9437 Human
Entrez Gene: 17086 Mouse
Entrez Gene: 117547 Rat
Omim: 604530 Human
SwissProt: O76036 Human
SwissProt: Q8C567 Mouse
SwissProt: Q9Z0H5 Rat
Unigene: 97084 Human
Unigene: 48231 Mouse
Unigene: 30049 Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
NKp46是很重要的的自然细胞毒受体,在自然杀伤作用中起关键作用。细胞毒性受体家族(NCRs)主要有:NKp46、NKp44和NKp30,其中NKp46和NKp30表达于所有静止和活化的NK细胞,而NKp44则选择性的表达于活化的NK细胞。靶细胞上的配体分子与NCRs的结合(交联)引发NK细胞的活化导致靶细胞的裂解和大量细胞因子的产生。现已确认NKp46和NKp44可以识别病毒上的配体分子红血球凝聚素,而NKp46则能识别肿瘤细胞上的乙酰硫酸多聚糖。
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