Home
>
Product
>
Antibody
>
Mouse Anti-hHb(H5A3)/FITC Conjugated antibody
background:
The human alpha globin gene cluster located on chromosome 16 spans about 30 kb and includes seven loci: 5'- zeta - pseudozeta - mu - pseudoalpha-1 - alpha-2 - alpha-1 - theta - 3'. The alpha-2 (HBA2) and alpha-1 (HBA1) coding sequences are identical. These genes differ slightly over the 5' untranslated regions and the introns, but they differ significantly over the 3' untranslated regions. Two alpha chains plus two beta chains constitute HbA, which in normal adult life comprises about 97% of the total hemoglobin; alpha chains combine with delta chains to constitute HbA-2, which with HbF (fetal hemoglobin) makes up the remaining 3% of adult hemoglobin. Alpha thalassemias result from deletions of each of the alpha genes as well as deletions of both HBA2 and HBA1; some nondeletion alpha thalassemias have also been reported. [provided by RefSeq, Jul 2008].
Database links:
Entrez Gene: 3039 Human
Entrez Gene: 3040 Human
Entrez Gene: 3047 Human
Omim: 14360 Human
Omim: 141900 Human
Omim: 14440 Human
SwissProt: P68871 Human
SwissProt: P69891 Human
SwissProt: P69905 Human
Unigene: 449630 Human
Unigene: 523443 Human
Unigene: 654744 Human
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
|
|