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Mouse Anti-CEA(B5)/FITC Conjugated antibody
background:
CEA-related cell adhesion molecules (CEACAM) belong to the carcinoembryonic antigen (CEA) family. It consists of seven CEACAM (CEACAM 1, CEACAM 3-CEACAM 8) and 11 pregnancy-specific glyco-protein (PSG 1-PSG 11) members. The CEA family proteins belong to the immunoglobulin (Ig) superfamily and are composed of one Ig variable-like (IgV) and a varying number (0-6) of Ig constant-like (IgC) domains. CEACAM molecules are membrane-bound either via a transmembrane domain or a glycosyl phosphatidyl inositol (GPI) anchor. CEACAM molecules are differentially expressed in epithelial cells or in leucocytes. Over-expression of CEA/ CEACAM 5 in tumors of epithelial origin is the basis of its wide-spread use as a tumor marker. The function of CEACAM family members varies widely: they function as cell adhesion molecules, tumor suppressors, regulators of lymphocyte and dendritic cell activation, receptors of Neisseria species and other bacteria.
Function:
Cell surface glycoprotein that plays a role in cell adhesion and in intracellular signaling. Receptor for E.coli Dr adhesins.
Subunit:
Homodimer. Binding of E.coli Dr adhesins leads to dissociation of the homodimer.
Subcellular Location:
Cell membrane; Lipid-anchor, GPI-anchor
Tissue Specificity:
Found in adenocarcinomas of endodermally derived digestive system epithelium and fetal colon.
Post-translational modifications:
Complex immunoreactive glycoprotein with a MW of 36 kDa comprising 60% carbohydrate.
Similarity:
Belongs to the immunoglobulin superfamily. CEA family.
Contains 7 Ig-like (immunoglobulin-like) domains.
Database links:
Entrez Gene: 1048 Human
Omim: 114890 Human
SwissProt: P06731 Human
Unigene: 709196 Human
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
CEA是一种胚胎性抗原,主要存在于胎儿消化道上皮组织,胰腺和肝癌中。CEA广泛存在各种上皮性肿瘤,尤其是胃肠道恶性肿瘤,CEA分布阳性类型与肿瘤的恶性度有关。CEA与EMA一样可作为上皮性恶性肿瘤的重要标记。
分子量为150-200 kDa。
该抗体与SLM1623M(检测)(Mouse Anti-Human CEA Monoclonal)配对使用;主要用于ELISA试剂盒,胶体金试剂条制备生产都很好。大量订购可来电商议。
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