Mouse Anti-phospho-FXYD1 (Ser68)/FITC Conjugated antibody

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FXYD domain containing ion transport regulator 1; Phospholemman; PLM; PLM_MOUSE; PLM_HUMAN;

Cat:

SLM51016M-FITC

Species Reactivity：

(predicted: Mouse,)

Immunogen：

KLH conjugated synthesised phosphopeptide derived from human FXYD1 around the phosphorylation site of Ser68

Format：

Lyophilized or Liquid

Storage instructions：

Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of ant

Buffer：

0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

Concentration：

1mg/ml

Clonality：

Monoclonal

Isotype：

IgG1

Applications：

not yet tested in other applications.optimal dilutions/concentrations should be determined by the end user.

Host：

Mouse

Calculated MW：

10kDa

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Unit:

Price: $596.00

Product PDFs

Datasheet: Down Datasheet

Other Information
Citations
Protein Attributes
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background:
PLM (FXYD1)is a member of a family of small membrane proteins that share a 35-amino acid signature sequence domain, beginning with the sequence PFXYD and containing 7 invariant and 6 highly conserved amino acids. FXYD2, also known as the gamma subunit of the Na,K-ATPase, regulates the properties of that enzyme. FXYD1 (phospholemman), FXYD2 (gamma), FXYD3 (MAT-8), FXYD4 (CHIF), and FXYD5 (RIC) have been shown to induce channel activity in experimental expression systems. PLM may be phosphorylated by several kinases, including protein kinase A, protein kinase C, NIMA kinase, and myotonic dystrophy kinase. It is thought to form an ion channel or regulate ion channel activity.

Function:
May have a functional role in muscle contraction. Induces a hyperpolarization-activated chloride current when exogenously expressed.

Subcellular Location:
Membrane; Single-pass type I membrane protein.

Tissue Specificity:
placenta, lung, liver, pancreas, uterus, bladder, prostate, small intestine and colon with mucosal lining. Very low levels in kidney, colon and small intestine without mucosa, prostate without endothelial lining, spleen, and testis.

Post-translational modifications:
Major plasma membrane substrate for cAMP-dependent protein kinase (PK-A) and protein kinase C (PK-C) in several different tissues. Phosphorylated in response to insulin and adrenergic stimulation. May be phosphorylated by DMPK (By similarity).
Palmitoylation increases half-life and stability, it is enhanced upon phosphorylation at Ser-88 by PKA.

Similarity:
Belongs to the FXYD family.

Database links:

Entrez Gene: 476487 Dog

Entrez Gene: 5348 Human

Entrez Gene: 56188 Mouse

Entrez Gene: 58971 Rat

Omim: 602359 Human

SwissProt: P56513 Dog

SwissProt: O00168 Human

SwissProt: Q9Z239 Mouse

SwissProt: O08589 Rat

Unigene: 442498 Human

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

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