Mouse Anti-NBR1/FITC Conjugated antibody

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1A1 3B; 1A13B; Cell migration-inducing gene 19 protein; KIAA0049; M17S2; Membrane component chromosome 17 surface marker 2; Membrane component chromosome 17 surface marker 2; MIG 19; MIG19; Migration inducing protein 19; NBR 1; Nbr1; NBR1_HUMAN; Neighbor

Cat:

SLM33384M-FITC

Immunogen：

Recombinant human NBR1 Protein

Format：

Lyophilized or Liquid

Storage instructions：

Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of ant

Buffer：

0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

Concentration：

1mg/ml

Clonality：

Monoclonal

Isotype：

IgG

Applications：

ICC=1:50-200IF=1:50-200not yet tested in other applications.optimal dilutions/concentrations should be determined by the end user.

Host：

Mouse

Calculated MW：

120kDa

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Unit:

Price: $596.00

Product PDFs

Datasheet: Down Datasheet

Other Information
Citations
Protein Attributes
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background:
The protein encoded by this gene was originally identified as an ovarian tumor antigen monitored in ovarian cancer. The encoded protein contains a B-box/coiled-coil motif, which is present in many genes with transformation potential. It functions as a specific autophagy receptor for the selective autophagic degradation of peroxisomes by forming intracellular inclusions with ubiquitylated autophagic substrates. This gene is located on a region of chromosome 17q21.1 that is in close proximity to the BRCA1 tumor suppressor gene. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Apr 2014]

Function:
Acts probably as a receptor for selective autophagosomal degradation of ubiquitinated targets.

Subcellular Location:
Cytoplasm. Cytoplasmic vesicle; autophagosome. Lysosome. Cytoplasm; myofibril; sarcomere; M line. In cardiac muscles localizes to the sarcomeric M line (By similarity). Is targeted to lysosomes for degradation.

Similarity:
Contains 1 OPR domain.
Contains 1 UBA domain.
Contains 1 ZZ-type zinc finger.

Database links:

Entrez Gene: 4077 Human

Entrez Gene: 17966 Mouse

Entrez Gene: 303554 Rat

Omim: 166945 Human

SwissProt: Q14596 Human

SwissProt: P97432 Mouse

SwissProt: Q501R9 Rat

Unigene: 277721 Human

Unigene: 708158 Human

Unigene: 784 Mouse

Unigene: 94975 Rat

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

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