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Mouse Anti-Cytokeratin 8/FITC Conjugated antibody
background:
This gene is a member of the type II keratin family clustered on the long arm of chromosome 12. Type I and type II keratins heteropolymerize to form intermediate-sized filaments in the cytoplasm of epithelial cells. The product of this gene typically dimerizes with keratin 18 to form an intermediate filament in simple single-layered epithelial cells. This protein plays a role in maintaining cellular structural integrity and also functions in signal transduction and cellular differentiation. Mutations in this gene cause cryptogenic cirrhosis. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jan 2012].
Function:
Together with KRT19, helps to link the contractile apparatus to dystrophin at the costameres of striated muscle.
Subunit:
Heterotetramer of two type I and two type II keratins. KRT8 associates with KRT18. Associates with KRT20. Interacts with HCV core protein and PNN. When associated with KRT19, interacts with DMD. Interacts with TCHP. Interacts with APEX1.
Subcellular Location:
Cytoplasm. Nucleus, nucleoplasm. Nucleus matrix.
Tissue Specificity:
Observed in muscle fibers accumulating in the costameres of myoplasm at the sarcolemma membrane in structures that contain dystrophin and spectrin. Expressed in gingival mucosa and hard palate of the oral cavity.
Post-translational modifications:
Phosphorylation on serine residues is enhanced during EGF stimulation and mitosis. Ser-74 phosphorylation plays an important role in keratin filament reorganization.
O-glycosylated. O-GlcNAcylation at multiple sites increases solubility, and decreases stability by inducing proteasomal degradation.
O-glycosylated (O-GlcNAcylated), in a cell cycle-dependent manner.
DISEASE:
Defects in KRT8 are a cause of cirrhosis (CIRRH) [MIM:215600].
Similarity:
Belongs to the intermediate filament family.
Database links:
Entrez Gene: 3856 Human
Entrez Gene: 16691 Mouse
Entrez Gene: 25626 Rat
Omim: 29660 Human
SwissProt: P05787 Human
SwissProt: P11679 Mouse
SwissProt: Q10758 Rat
Unigene: 533782 Human
Unigene: 708445 Human
Unigene: 358618 Mouse
Unigene: 11083 Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
结构蛋白（Structural Proteins）
上皮细胞胞质中的骨架蛋白除微丝（肌动蛋白）、微管蛋白外，主要是细胞角蛋白（cytokeratins，CK）。CK8也是上皮细胞的特征性标记物：CK8存在于某些正常腺上皮及其肿瘤，包括许多导管上皮和腺上皮，如结肠、胃、小肠、气管的上皮和尿路上皮。CK8主要用于腺癌和导管癌的诊断，鳞状细胞癌一般不表达CK8。
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