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Mouse Anti-GRP78/Bip/FITC Conjugated antibody
background:
The 78 kDa glucose regulated protein/BiP (GRP78) belongs to the family of ~70 kDa heat shock proteins (HSP 70). GRP78 is a resident protein of the endoplasmic reticulum (ER) and may associate transiently with a variety of newly synthesized secretory and membrane proteins or permanently with mutant or defective proteins that are incorrectly folded, thus preventing their export from the ER lumen. GRP78 is a highly conserved protein that is essential for cell viability. The highly conserved sequence Lys-Asp-Glu-Leu (KDEL) is present at the C terminus of GRP78 and other resident ER proteins including glucose regulated protein 94 (GRP 94) and protein disulfide isomerase (PDI). The presence of carboxy terminal KDEL appears to be necessary for retention and appears to be sufficient to reduce the secretion of proteins from the ER. This retention is reported to be mediated by a KDEL receptor.
Function:
Probably plays a role in facilitating the assembly of multimeric protein complexes inside the ER.
Subcellular Location:
Endoplasmic reticulum lumen. Melanosome. Identified by mass spectrometry in melanosome fractions from stage I to stage IV.
DISEASE:
Note=Autoantigen in rheumatoid arthritis.
Similarity:
Belongs to the heat shock protein 70 family.
Database links:
Entrez Gene: 3309 Human
Entrez Gene: 14828 Mouse
Entrez Gene: 25617 Rat
Omim: 138120 Human
SwissProt: P11021 Human
SwissProt: P20029 Mouse
SwissProt: P06761 Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
葡萄糖调节蛋白78是热休克蛋白70家族的成员之一又称:热休克蛋白70蛋白5,作为一种分子伴侣在蛋白质的折叠和转运过程及内质网应激反应中发挥重要作用.它在多种肿瘤组织中呈高表达.
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