Mouse Anti-CDX2/FITC Conjugated antibody

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cau-dal-related homeobox transcription factor 2; Caudal type homeo box 2; Caudal type homeobox protein 2; caudal type homeobox transcription factor 2; CDX 2; CDX 3; CDX3; Homeobox protein CDX-2; Homeobox protein CDX2; CDX2_HUMAN.

Cat:

SLM33063M-FITC

Species Reactivity：

(predicted: Human,Mouse,Rat,)

Immunogen：

KLH conjugated synthetic peptide derived from human CDX2

Format：

Lyophilized or Liquid

Storage instructions：

Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of ant

Buffer：

0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

Concentration：

1mg/ml

Clonality：

Monoclonal

Isotype：

IgG

Applications：

IF=1:50-200not yet tested in other applications.optimal dilutions/concentrations should be determined by the end user.

Host：

Mouse

Calculated MW：

34kDa

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Unit:

Price: $596.00

Product PDFs

Datasheet: Down Datasheet

Other Information
Citations
Protein Attributes
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background:
This gene is a member of the caudal-related homeobox transcription factor gene family. The encoded protein is a major regulator of intestine-specific genes involved in cell growth an differentiation. This protein also plays a role in early embryonic development of the intestinal tract. Aberrant expression of this gene is associated with intestinal inflammation and tumorigenesis. [provided by RefSeq, Jan 2012]

Function:
Involved in the transcriptional regulation of multiple genes expressed in the intestinal epithelium. Important in broad range of functions from early differentiation to maintenance of the intestinal epithelial lining of both the small and large intestine.

Subcellular Location:
Nucleus.

Post-translational modifications:
Phosphorylation of Ser-60 mediates the transactivation capacity.

Similarity:
Belongs to the Caudal homeobox family.
Contains 1 homeobox DNA-binding domain.

Database links:

Entrez Gene: 1045 Human

Entrez Gene: 12591 Mouse

Entrez Gene: 66019 Rat

Omim: 600297 Human

SwissProt: Q99626 Human

SwissProt: P43241 Mouse

Unigene: 174249 Human

Unigene: 20358 Mouse

Unigene: 64495 Rat

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

核转录因子抗体
CDX2表达主要用于消化系统肿瘤及癌前病变的研究。用于与肿瘤的增值、分化、大小、临床分期及分化程度等关系方面的研究。CDX2是一种肠特异的转录因子，CDX2能够调节肠上皮细胞的增殖和分化，定位于肠上皮的绒毛和隐窝表面。据报道95%以上的浸润性结/直肠癌中均可检出CDX2阳性表达，也可在胃癌和卵巢黏液性腺癌中表达。

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