Mouse Anti-CD2/FITC Conjugated antibody

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T-cell surface antigen CD2; CD 2; CD2 antigen; CD2 molecule; LFA2; LFA3 receptor; Lymphocyte function antigen 2; p50; Rosette receptor; Sheep erythrocyte receptor; Sheep red blood cell receptor; SRBC; T cell surface antigen CD2; T cell surface antigen T11

Cat:

SLM33075M-FITC

Species Reactivity：

(predicted: Human,Mouse,Rat,)

Immunogen：

KLH conjugated synthetic peptide derived from human CD2

Format：

Lyophilized or Liquid

Storage instructions：

Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of ant

Buffer：

0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

Concentration：

1mg/ml

Clonality：

Monoclonal

Isotype：

IgG

Applications：

IF=1:50-200not yet tested in other applications.optimal dilutions/concentrations should be determined by the end user.

Host：

Mouse

Calculated MW：

37kDa

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Unit:

Price: $596.00

Product PDFs

Datasheet: Down Datasheet

Other Information
Citations
Protein Attributes
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background:
CD2 is a surface antigen of the human T lymphocyte lineage that is expressed on all peripheral blood T cells. It is one of the earliest T cell markers, being present on more than 95% of thymocytes; it is also found on some natural killer cells but not on B lymphocytes.
CD2 interacts with lymphocyte function associated antigen (LFA3) and CD48/BCM1 to mediate adhesion between T cells and other cell types. CD2 is implicated in the triggering of T cells, the cytoplasmic domain is implicated in the signaling function. It is useful for the identification of lymphomas and leukaemias of T cell origin.

Function:
CD2 interacts with lymphocyte function-associated antigen (LFA-3) and CD48/BCM1 to mediate adhesion between T-cells and other cell types. CD2 is implicated in the triggering of T-cells, the cytoplasmic domain is implicated in the signaling function.

Subunit:
Interacts with CD2AP. Interacts with PSTPIP1.

Subcellular Location:
Membrane; Single-pass type I membrane protein.

Similarity:
Contains 1 Ig-like C2-type (immunoglobulin-like) domain.
Contains 1 Ig-like SLVtype (immunoglobulin-like) domain.

Database links:

Entrez Gene: 914 Human

Entrez Gene: 12481 Mouse

Entrez Gene: 497761 Rat

Omim: 186990 Human

SwissProt: P06729 Human

SwissProt: P08920 Mouse

SwissProt: P08921 Rat

Unigene: 523500 Human

Unigene: 22842 Mouse

Unigene: 10328 Rat

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

CD2分子又称T11、绵羊红细胞受体（ER）、淋巴细胞功能相关抗原2（LFA-2）和Leu5，是人T淋巴细胞表面的单链糖蛋白.CD2分子是分布于胸腺细胞及所有成熟T淋巴细胞和大部分自然杀伤细胞表面的特征性分化抗原。CD2具有调节T淋巴细胞分化、成熟、激活和凋亡等功能，CD2与LFA-3之间的粘附功能对于T淋巴细胞TCR识别外来抗原与APC细胞表面MHC抗原复合物、肿瘤抗原、病毒感染靶细胞以及同种异体抗原均有重要的辅助作用。
最近研究表明，CD48和CD59也是CD2的配体，参与T细胞的粘附和细胞间的相互作用,此外，CD2可以与其它膜分子如CD44、CD45的功能有关。CD2具有对T细胞的旁路激活途径作用。

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