background:
This gene is unusual in that its coding sequence is derived almost entirely from a cluster of different Alu repeat sequences. However, the mRNA and the encoded protein have been shown to be expressed in neurons, and overexpressed in brains with Alzheimer's disease. In vitro studies also demonstrated that abnormal expression of this gene promoted neuritic sprouting and cell death, associated with dementia in Alzheimer's disease.
Database links:
GenBank: AAC08737
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
AD7SLCNTP是存在于神经元中的一种41Kda的蛋白质,在AD患者脑内选择性升高,和其病理过程相关,AD7SLCNTP基因也只在神经元表达,AD患者脑脊液中AD7SLCNTP表达升高, AD7SLCNTP作为AD早期诊断和确诊的生物化学标志正引起越来越多的关注.
|
|