Rabbit Anti-NALP3/CIAS1 antibody

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LRR and PYD domains-containing protein 3; AGTAVPRL; AII/AVP antibody Angiotensin/vasopressin receptor AII/AVP like; Angiotensin/vasopressin receptor AII/AVP-like; C1orf7; Caterpiller protein 1.1; CIAS 1; CIAS1; CLR1.1; Cold autoinflammatory syndrome 1; Co

Cat:

SL10021R

Species Reactivity：

Human,Mouse,Rat,Dog,

Immunogen：

KLH conjugated synthetic peptide derived from human Cryopyrin:15-120/1036

Format：

Liquid

Storage instructions：

Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.

Concentration：

1mg/ml

Clonality：

Polyclonal

Isotype：

IgG

Applications：

WB=1:500-2000ELISA=1:5000-10000IHC-P=1:100-500IHC-F=1:100-500Flow-Cyt=2ug/TestIF=1:200-800（Paraffin sections need to do antigen repair）not yet tested in other applications.optimal dilutions/concentrations should be determined by the end user.

Host：

Rabbit

Product Overview：

Sample: Lane 1: RAW264.7 (Mouse) Cell Lysate at 30 ug Lane 2: Thymus (Mouse) Lysate at 40 ug Primary: Anti- NALP3’CIAS1 (SL10021R) at 1/1000 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 118 kD Observed band size: 118 kD Sample: Lane 1: Cerebrum (Mouse) Lysate at 40 ugLane 2: Large intestine (Mouse) Lysate at 40 ugLane 3: Thymus (Mouse) Lysate at 40 ugLane 4: Lung (Mouse) Lysate at 40 ugLane 5: Cerebrum (Rat) Lysate at 40 ugLane 6: Thymus (Rat) Lysate at 40 ugLane 7: Lung (Rat) Lysate at 40 ugLane 8: Jurkat (Human) cell Lysate at 30 ugPrimary: Anti-NALP3/CIAS1 (SL10021R) at 1/1000 dilutionSecondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilutionPredicted band size: 118 kDObserved band size: 118 kDSample: Thymus (Rat) Lysate at 40 ugPrimary: Anti-NALP3’CIAS1 (SL10021R) at 1/1000 dilutionSecondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilutionPredicted band size: 118 kDObserved band size: 120 kDSample: Lymph node (Mouse) Lysate at 40 ugPrimary: Anti- NALP3’CIAS1 (SL10021R) at 1/1000 dilutionSecondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilutionPredicted band size: 114 kDObserved band size: 114 kDSample: Spleen (Mouse) Lysate at 40 ugThymus (Mouse) Lysate at 40 ugPrimary: Anti- NALP3’CIAS1 (SL10021R) at 1/1000 dilutionSecondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilutionPredicted band size: 118 kDObserved band size: 118 kDSample: Raji Cell (Human) Lysate at 30 ugMDA-MB-231 Cell (Human) Lysate at 30 ugPrimary: Anti- CIAS1 (SL10021R) at 1/300 dilutionSecondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilutionPredicted band size: 114kDObserved band size: 114kDSample: Raji (human)cell Lysate at 40 ugMCF-7 (human)cell Lysate at 40 ugsiha (human)cell Lysate at 40 ugPrimary: Anti- NALP3'CIAS1 (SL10021R)at 1/300 dilutionSecondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilutionPredicted band size: 114kDObserved band size: 114 kDTissue/cell: mouse embryo tissue; 4% Paraformaldehyde-fixed and paraffin-embedded; Antigen retrieval: citrate buffer ( 0.01M, pH 6.0 ), Boiling bathing for 15min; Block endogenous peroxidase by 3% Hydrogen peroxide for 30min; Blocking buffer (normal goat serum,SLC0005) at 37℃ for 20 min; Incubation: Anti-Cryopyrin/CIAS1/NALP3 Polyclonal Antibody, Unconjugated(SL10021R) 1:200, overnight at 4°C, followed by conjugation to the secondary antibody(SP-0023) and DAB(SLC0010) stainingParaformaldehyde-fixed, paraffin embedded (Human liver cancer); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with (NALP3/CIAS1) Polyclonal Antibody, Unconjugated (SL10021R) at 1:400 overnight at 4°C, followed by operating according to SP Kit(Rabbit) (sp-0023) instructionsand DAB staining.Tissue/cell: human lung carcinoma; 4% Paraformaldehyde-fixed and paraffin-embedded; Antigen retrieval: citrate buffer ( 0.01M, pH 6.0 ), Boiling bathing for 15min; Block endogenous peroxidase by 3% Hydrogen peroxide for 30min; Blocking buffer (normal goat serum,SLC0005) at 37℃ for 20 min; Incubation: Anti-Cryopyrin/CIAS1/NALP3 Polyclonal Antibody, Unconjugated(SL10021R) 1:200, overnight at 4°C, followed by conjugation to the secondary antibody(SP-0023) and DAB(SLC0010) stainingThis image was generously provided by Adib Zendedel, PhD from RWTH Aachen University. Formalin-fixed and paraffin embedded rat spinal cord tissue labeled with Rabbit Anti-Cryopyrin Polyclonal Antibody, Unconjugated (SL10021R) at 1:300 followed by conjugation to a secondary antibodyParaformaldehyde-fixed, paraffin embedded (Human liver cancer); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with (NALP3/CIAS1) Polyclonal Antibody, Unconjugated (SL10021R) at 1:400 overnight at 4°C, followed by a conjugated Goat Anti-Rabbit IgG antibody (SL0295G-AF488) for 90 minutes, and DAPI for nuclei staining.Blank control: Jurkat. Primary Antibody (green line): Rabbit Anti-NALP3/CIAS1 antibody (SL10021R) Dilution: 2μg /10^6 cells; Isotype Control Antibody (orange line): Rabbit IgG . Secondary Antibody : Goat anti-rabbit IgG-FITCDilution: 1μg /test. ProtocolThe cells were fixed with 4% PFA (10min at room temperature)and then permeabilized with 90% ice-cold methanol for 20 min at-20℃.The cells were then incubated in 5%BSA to block non-specific protein-protein interactions for 30 min at room temperature .Cells stained with Primary Antibody for 30 min at room temperature. The secondary antibody used for 40 min at room temperature. Acquisition of 20,000 events was performed.

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Unit:

Price: $220.00

Product PDFs

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Other Information
Citations
Protein Attributes
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May function as an inducer of apoptosis. Interacts selectively with ASC and this complex may function as an upstream activator of NF-kappa-B signaling. Inhibits TNF-alpha induced activation and nuclear translocation of RELA/NF-KB p65. Also inhibits transcriptional activity of RELA. Activates caspase-1 in response to a number of triggers including bacterial or viral infection which leads to processing and release of IL1B and IL18.

Function:
May function as an inducer of apoptosis. Interacts selectively with ASC and this complex may function as an upstream activator of NF-kappa-B signaling. Inhibits TNF-alpha induced activation and nuclear translocation of RELA/NF-KB p65. Also inhibits transcriptional activity of RELA. Activates caspase-1 in response to a number of triggers including bacterial or viral infection which leads to processing and release of IL1B and IL18.

Subcellular Location:
Cytoplasm.

Tissue Specificity:
Expressed in blood leukocytes. Strongly expressed in polymorphonuclear cells and osteoblasts. Undetectable or expressed at a lower magnitude in B- and T-lymphoblasts, respectively. High level of expression detected in chondrocytes. Detected in non-keratinizing epithelia of oropharynx, esophagus and ectocervix and in the urothelial layer of the bladder.

DISEASE:
Defects in NLRP3 are the cause of familial cold autoinflammatory syndrome type 1 (FCAS1) [MIM:120100]; also known as familial cold urticaria. FCAS are rare autosomal dominant systemic inflammatory diseases characterized by episodes of rash, arthralgia, fever and conjunctivitis after generalized exposure to cold.
Defects in NLRP3 are a cause of Muckle-Wells syndrome (MWS) [MIM:191900]; also known as urticaria-deafness-amyloidosis syndrome. MWS is a hereditary periodic fever syndrome characterized by fever, chronic recurrent urticaria, arthralgias, progressive sensorineural deafness, and reactive renal amyloidosis. The disease may be severe if generalized amyloidosis occurs.
Defects in NLRP3 are the cause of chronic infantile neurologic cutaneous and articular syndrome (CINCA) [MIM:607115]; also known as neonatal onset multisystem inflammatory disease (NOMID). CINCA is a rare congenital inflammatory disorder characterized by a triad of neonatal onset of cutaneous symptoms, chronic meningitis and joint manifestations with recurrent fever and inflammation.

Similarity:
Belongs to the NLRP family.
Contains 1 DAPIN domain.
Contains 9 LRR (leucine-rich) repeats.
Contains 1 NACHT domain.

SWISS:
Q96P20

Gene ID:
114548

Database links:

Entrez Gene: 114548 Human

Entrez Gene: 216799 Mouse

Entrez Gene: 287362 Rat

Omim: 606416 Human

SwissProt: Q96P20 Human

SwissProt: Q8R4B8 Mouse

Unigene: 159483 Human

Unigene: 54174 Mouse

Picture

Sample:
Lane 1: Cerebrum (Mouse) Lysate at 40 ug
Lane 2: Large intestine (Mouse) Lysate at 40 ug
Lane 3: Thymus (Mouse) Lysate at 40 ug
Lane 4: Lung (Mouse) Lysate at 40 ug
Lane 5: Cerebrum (Rat) Lysate at 40 ug
Lane 6: Thymus (Rat) Lysate at 40 ug
Lane 7: Lung (Rat) Lysate at 40 ug
Lane 8: Jurkat (Human) cell Lysate at 30 ug
Primary: Anti-NALP3/CIAS1 (SL10021R) at 1/1000 dilution
Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution
Predicted band size: 118 kD
Observed band size: 118 kD

Sample:
Thymus (Rat) Lysate at 40 ug
Primary: Anti-NALP3’CIAS1 (SL10021R) at 1/1000 dilution
Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution
Predicted band size: 118 kD
Observed band size: 120 kD

Sample:
Lymph node (Mouse) Lysate at 40 ug
Primary: Anti- NALP3’CIAS1 (SL10021R) at 1/1000 dilution
Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution
Predicted band size: 114 kD
Observed band size: 114 kD

Sample:
Spleen (Mouse) Lysate at 40 ug
Thymus (Mouse) Lysate at 40 ug
Primary: Anti- NALP3’CIAS1 (SL10021R) at 1/1000 dilution
Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution
Predicted band size: 118 kD
Observed band size: 118 kD

Sample:
Raji Cell (Human) Lysate at 30 ug
MDA-MB-231 Cell (Human) Lysate at 30 ug
Primary: Anti- CIAS1 (SL10021R) at 1/300 dilution
Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution
Predicted band size: 114kD
Observed band size: 114kD

Sample:
Raji (human)cell Lysate at 40 ug
MCF-7 (human)cell Lysate at 40 ug
siha (human)cell Lysate at 40 ug
Primary: Anti- NALP3'CIAS1 (SL10021R)at 1/300 dilution
Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution
Predicted band size: 114kD
Observed band size: 114 kD

Tissue/cell: mouse embryo tissue; 4% Paraformaldehyde-fixed and paraffin-embedded;
Antigen retrieval: citrate buffer ( 0.01M, pH 6.0 ), Boiling bathing for 15min; Block endogenous peroxidase by 3% Hydrogen peroxide for 30min; Blocking buffer (normal goat serum,SLC0005) at 37℃ for 20 min;
Incubation: Anti-Cryopyrin/CIAS1/NALP3 Polyclonal Antibody, Unconjugated(SL10021R) 1:200, overnight at 4°C, followed by conjugation to the secondary antibody(SP-0023) and DAB(SLC0010) staining

Paraformaldehyde-fixed, paraffin embedded (Human liver cancer); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with (NALP3/CIAS1) Polyclonal Antibody, Unconjugated (SL10021R) at 1:400 overnight at 4°C, followed by operating according to SP Kit(Rabbit) (sp-0023) instructionsand DAB staining.

Tissue/cell: human lung carcinoma; 4% Paraformaldehyde-fixed and paraffin-embedded;
Antigen retrieval: citrate buffer ( 0.01M, pH 6.0 ), Boiling bathing for 15min; Block endogenous peroxidase by 3% Hydrogen peroxide for 30min; Blocking buffer (normal goat serum,SLC0005) at 37℃ for 20 min;
Incubation: Anti-Cryopyrin/CIAS1/NALP3 Polyclonal Antibody, Unconjugated(SL10021R) 1:200, overnight at 4°C, followed by conjugation to the secondary antibody(SP-0023) and DAB(SLC0010) staining

This image was generously provided by Adib Zendedel, PhD from RWTH Aachen University. Formalin-fixed and paraffin embedded rat spinal cord tissue labeled with Rabbit Anti-Cryopyrin Polyclonal Antibody, Unconjugated (SL10021R) at 1:300 followed by conjugation to a secondary antibody

Paraformaldehyde-fixed, paraffin embedded (Human liver cancer); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with (NALP3/CIAS1) Polyclonal Antibody, Unconjugated (SL10021R) at 1:400 overnight at 4°C, followed by a conjugated Goat Anti-Rabbit IgG antibody (SL0295G-AF488) for 90 minutes, and DAPI for nuclei staining.

Blank control: Jurkat.
Primary Antibody (green line): Rabbit Anti-NALP3/CIAS1 antibody (SL10021R)
Dilution: 2μg /10^6 cells;
Isotype Control Antibody (orange line): Rabbit IgG .
Secondary Antibody : Goat anti-rabbit IgG-FITC
Dilution: 1μg /test.
Protocol
The cells were fixed with 4% PFA (10min at room temperature)and then permeabilized with 90% ice-cold methanol for 20 min at-20℃.The cells were then incubated in 5%BSA to block non-specific protein-protein interactions for 30 min at room temperature .Cells stained with Primary Antibody for 30 min at room temperature. The secondary antibody used for 40 min at room temperature. Acquisition of 20,000 events was performed.

Product Feedback Wall

Specific References (47) | SL10021R has been referenced in 47 publications.

[IF=8.469] Pang, Qi. et al. Irisin protects against vascular calcification by activating autophagy and inhibiting NLRP3-mediated vascular smooth muscle cell pyroptosis in chronic kidney disease. Cell Death Dis. 2022 Mar;13(3):1-15 IF ; Mouse.

PubMed:35354793

[IF=3.04] Niu X et al. Harmine mitigates LPS-induced acute kidney injury through inhibition of the TLR4-NF-κB/NLRP3 inflammasome signalling pathway in mice. Eur J Pharmacol. 2019 Apr 15;849:160-169. IHSLCP&WB ; Mouse.

PubMed:30716318

[IF=4.225] Liu P et al. Harmine Ameliorates Cognitive Impairment by Inhibiting NLRP3 Inflammasome Activation and Enhancing the BDNF/TrkB Signaling Pathway in STZ-Induced Diabetic Rats. Front Pharmacol. 2020 May 1;11:535. WB/IHC/IF ; Rat.

PubMed:32425784

[IF=2.615] Wei Yu. et al. Curcumin suppresses doxorubicin-induced cardiomyocyte pyroptosis via a PI3K/Akt/mTOR-dependent manner. Cardiovasc Diagn The. 2020 Aug; 10(4): 752–769 WB ; Mouse.

PubMed:32968631

[IF=8.469] Zheng, Jie. et al. A novel function of NLRP3 independent of inflammasome as a key transcription factor of IL-33 in epithelial cells of atopic dermatitis. Cell Death Dis. 2021 Sep;12(10):1-12 IHC ; mouse.

PubMed:34561424

[IF=3.683] Shi, Chenxi. et al. Dihydromyricetin alleviates Escherichia coli lipopolysaccharide-induced hepatic injury in chickens by inhibiting the NLRP3 inflammasome. Vet Res. 2022 Dec;53(1):1-16 WB ; Chicken.

PubMed:35073994

[IF=3.59] Jie Ma. et al. The Effect of MaxiK Channel on Regulating the Activation of NLRP3 Inflammasome in Rats of Blast-induced Traumatic Brain Injury. Neuroscience. 2022 Feb;482:132 IHC ; Rat.

PubMed:34923036

[IF=4.268] Xiping Yang. et al. The piperine derivative HJ105 inhibits Aβ1-42-induced neuroinflammation and oxidative damage via the Keap1-Nrf2-TXNIP axis. Phytomedicine. 2021 Apr;:153571 WB ; Rat.

PubMed:33994056

[IF=3.056] Carmen Hummel. et al. Expression and Cell Type-specific Localization of Inflammasome Sensors in the Spinal Cord of SOD1(G93A) Mice and Sporadic Amyotrophic lateral sclerosis Patients. Neuroscience. 2021 Mar;: IHC ; Mouse.

PubMed:33781799

[IF=4.966] Hui Che. et al. Melatonin exerts neuroprotective effects by inhibiting neuronal pyroptosis and autophagy in STZ‐induced diabetic mice. Faseb J. 2020 Oct;34(10):14042-14054 WB,IHC ; Mouse, Human.

PubMed:32910484

[IF=3.9] Dong Zhixia. et al. Adiponectin Inhibits NLRP3 Inflammasome Activation in Nonalcoholic Steatohepatitis via AMPK-JNK/ErK1/2-NFκB/ROS Signaling Pathways. Front Med-Lausanne. 2020 Nov;7:705 WB ; Mouse.

PubMed:33251225

[IF=4.362] Zhou Wen. et al. Enhanced Autolysosomal Function Ameliorates the Inflammatory Response Mediated by the NLRP3 Inflammasome in Alzheimer’s Disease. Front Aging Neurosci. 2021 Feb;13:46 WB ; Mouse.

PubMed:10.3389/fnagi.2021.629891

[IF=3.647] Guan L et al. Puerarin ameliorates retinal ganglion cell damage induced by retinal ischemia/reperfusion through inhibiting the activation of TLR4/NLRP3 inflammasome. Life Sci . 2020 Sep 1;256:117935. WB ; Rat.

PubMed:32526286

[IF=6.304] Hanwen Li et al. P2Y 14 receptor has a critical role in acute gouty arthritis by regulating pyroptosis of macrophages. Cell Death Dis.2020 May 26;11(5):394. WB ; Rat.

PubMed:32457291

[IF=3.361] Yang X et al. HJ22, a Novel derivative of piperine, Attenuates ibotenic acid-induced cognitive impairment, oxidativestress, apoptosis and inflammation via inhibiting the protein-protein interaction of Keap1-Nrf2. Int Immunopharmacol. 2020 Mar 16;83:106383. IHC,WB ; rat.

PubMed:32193099

[IF=3.266] Guan X et al. Estrogen deficiency aggravates apical periodontitis by regulating NLRP3/caspase-1/IL-1β axis. Am J Transl Res. 2020 Feb 15;12(2):660-671. WB,IHC ; human.

PubMed:32194913

[IF=1.773] Qu XY et al. XingNaoJing injections protect against cerebral ischemia/reperfusion injury and alleviate blood-brain barrier disruption in rats, through an underlying mechanism of NLRP3 inflammasomes suppression. Chin J Nat Med. 2019 Jul;17(7):498-505. WB&IHSLCP ; Rat.

PubMed:31514981

[IF=3.118] Peng XP et al. The protective effect of oleanolic acid on NMDA-induced MLE-12 cells apoptosis and lung injury in mice by activating SIRT1 and reducing NF-κB acetylation.Int Immunopharmacol. 2019 May;70:520-529. WB ; Mouse.

PubMed:30901738

[IF=5.589] WB + ELISA ; Mouse.

PubMed:31863983

[IF=1.719] Qu XY et al. Astragaloside IV protects against cisplatin-induced liver and kidney injury via autophagy-mediated inhibition of NLRP3 in rats.The Journal of Toxicological Sciences,2019 44(3), 167–175. IHSLCP&WB ; Rat.

PubMed:doi:10.2131/jts.44.167

[IF=4.263] Wu X et al.The role of Ca 2+ in acid-sensing ion channel 1a-mediated chondrocyte pyroptosis in rat adjuvant arthritis.(2018) Lab Invest. WB ; Rat.

PubMed:30487596

[IF=6.187] Debye et al. Neurodegeneration and NLRP3 inflammasome expression in the anterior thalamus of SOD1(G93A) ALS mice. (2016) Brain.Pathol. IHSLCP,IHSLCP-IF ; Mouse.

PubMed:27176990

[IF=5.168] Yu, Chengyuan, et al. "Chronic obstructive sleep apnea promotes aortic remodeling in canines through miR-145/Smad3 signaling pathway." Oncotarget 8.23 (2017): 37705. WB ; Dog.

PubMed:28465478

[IF=5.4] Zendedel, Adib, et al. "Estrogen Attenuates Local Inflammasome Expression and Activation after Spinal Cord Injury." Molecular Neurobiology (2017): 1-12. WB, IF(IHSLCP) ; Rat.

PubMed:28127698

[IF=4.21] Zhou, Tianwei E., et al. "Choroidal Involution Is Associated with a Progressive Degeneration of the Outer Retinal Function in a Model of Retinopathy of Prematurity: Early Role for IL-1β." The American Journal of Pathology (2016). IHSLCF ; Rat.

PubMed:27768863

[IF=5.29] Zendedel, Adib, et al. "Activation and Regulation of NLRP3 Inflammasome by Intrathecal Application of SDF-1a in a Spinal Cord Injury Model." Molecular Neurobiology (2015): 1-13. WB ; Rat.

PubMed:2597248

[IF=4.095] Slowik A et al. Impact of steroid hormones E2 and P on the NLRP3/ASC/Casp1 axis in primary mouse astroglia and BSLV2 cells after in vitro hypoxia.J Steroid Biochem Mol Biol. 2018 Oct;183:18-26. WB&ICF ; Murine.

PubMed:29772377

[IF=1.813] Zhu Hui-Zheng. et al. Xiaoyaosan Exerts Therapeutic Effects on the Colon of Chronic Restraint Stress Model Rats via the Regulation of Immunoinflammatory Activation Induced by the TLR4/NLRP3 Inflammasome Signaling Pathway. Evid-Based Compl Alt. 2021;2021:6673538 WB ; Rat.

PubMed:33505499

[IF=2.447] Zijie Wei. et al. KDM2B overexpression prevents myocardial ischemia‑reperfusion injury in rats through regulating inflammatory response via the TLR4/NF‑κB p65 axis. Exp Ther Med. 2022 Feb;23(2):1-8 WB ; Rat.

PubMed:35069835

[IF=5.396] Shi-Yong Zhu. et al. Lycopene Ameliorates Atrazine-Induced Pyroptosis in Spleen via Suppressing the Ox-mtDNA/Nlrp3 Inflammasome Pathway. Food Funct. 2021 Nov;: IF ; Mouse.

PubMed:10.1039/D1FO02857J

[IF=3.921] Meiyun Cai. et al. Kaemperfol alleviates pyroptosis and microglia-mediated neuroinflammation in Parkinson's disease via inhibiting p38MAPK/NF-κB signaling pathway. Neurochem Int. 2021 Nov;:105221 WB ; Rat.

PubMed:34780806

[IF=6.6] Maryam Baazm. et al. Regulation of Inflammasomes by Application of Omega-3 Polyunsaturated Fatty Acids in a Spinal Cord Injury Model. Cells-Basel. 2021 Nov;10(11):3147 WB ; Rat.

PubMed:34831370

[IF=6.543] Wen Lianghe. et al. Melatonin Exerts Cardioprotective Effects by Inhibiting NLRP3 Inflammasome-Induced Pyroptosis in Mice following Myocardial Infarction. Oxid Med Cell Longev. 2021;2021:5387799 WB,IF ; mouse.

PubMed:34512865

[IF=7.561] You Zhou. et al. Overexpression of lncRNA TUG1 Alleviates NLRP3 Inflammasome-Mediated Cardiomyocyte Pyroptosis Through Targeting the miR-186-5p/XIAP Axis in Coronary Microembolization-Induced Myocardial Damage. Front Immunol. 2021; 12: 637598 WB ; Rat.

PubMed:34163467

[IF=6.6] Chinmaya Panda. et al. Aggregated Tau-PHF6 (VQIVYK) Potentiates NLRP3 Inflammasome Expression and Autophagy in Human Microglial Cells. Cells-Basel. 2021 Jul;10(7):1652 ICC ; Human.

PubMed:34209408

[IF=2.678] Huan Xiao. et al. Effects of Mycobacterium vaccae Aerosol Inhalation on Airway Inflammation in Asthma Mouse Model. 2021 May 04 IHC ; Mouse.

PubMed:33945334

[IF=1.695] Yaru Huang. et al. Dexmedetomidine attenuates myocardial ischemia-reperfusion injury in vitro by inhibiting NLRP3 Inflammasome activation. Bmc Anesthesiol. 2021 Dec;21(1):1-12 WB ; Rat.

PubMed:33823789

[IF=3.758] Lei Xianghong. et al. Micheliolide Attenuates Lipopolysaccharide-Induced Inflammation by Modulating the mROS/NF-κB/NLRP3 Axis in Renal Tubular Epithelial Cells. Mediat Inflamm. 2020;2020:3934769 WB ; Rat.

PubMed:32879619

[IF=3.701] Ying Sun. et al. Neuroprotective effects of natural cordycepin on LPS-induced Parkinson’s disease through suppressing TLR4/NF-κB/NLRP3-mediated pyroptosis. J Funct Foods. 2020 Dec;75:104274 WB ; Mouse.

PubMed:10.1016/j.jff.2020.104274

[IF=7.919] Chen Y et al. A selected small molecule prevents inflammatory osteolysis through restraining osteoclastogenesis by modulating PTEN activityClin Transl Med.2020 Dec;10(8):e48. WB、IHC ; Mouse.

PubMed:33377656

[IF=3.743] Chen Y et al. Curcumin attenuates potassium oxonate-induced hyperuricemia and kidney inflammation in mice. Biomed Pharmacother. 2019 Jul 27;118:109195. WB ; Mouse.

PubMed:31362244

[IF=1.286] Kariya S et al. NLRP3 inflammasome expression in lipopolysaccharide-induced otitis media. Acta Otolaryngol. 2018 Dec;138(12):1061-1065. IHSLCP ; Mouse.

PubMed:30676848

[IF=1.837] Qu X et al. Autophagy inhibition‐enhanced assembly of the NLRP3 inflammasome is associated with cisplatin‐induced acute injury to the liver and kidneys in rats. (2018) J Biochem Mol Toxicol.e22208. IHC,WB ; Rat.

PubMed:30291731

[IF=3.545] Zhang X et al. NLRP3 Inflammasome Is Involved in Calcium-sensing receptor-induced Aortic Remodeling in SHRs. Mediators Inflamm. 2019 Feb 13;2019:6847087. WB ; Rat.

PubMed:30906225

[IF=5.1] Zhang, Xiaohui, et al. "H3 Relaxin Protects Against Myocardial Injury in Experimental Diabetic Cardiomyopathy by Inhibiting Myocardial Apoptosis, Fibrosis and Inflammation." Cellular Physiology and Biochemistry 43.4 (2017): 1311-1324. WB ; Rat.

PubMed:28992627

[IF=5.4] Heitzer, Marius, et al. "Administration of 17β-Estradiol Improves Motoneuron Survival and Down-regulates Inflammasome Activation in Male SOD1 (G93A) ALS Mice." Molecular Neurobiology: 1-15. WB ; Mouse.

PubMed:27957136

[IF=4.29] Fernandez, Melissa Victoria, et al. "Ion efflux and influenza infection trigger NLRP3 inflammasome signaling in human dendritic cells." Journal of leukocyte biology 99.5 (2016): 723-734. WB ; Human.

PubMed:26574023