Rabbit Anti-E-Selectin antibody

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CD 62E; CD26E; CD62E antigen; CD62 antigen-like family member E; E selectin; ELAM 1; ELAM; ELAM-1; ELAM1; Endothelial adhesion molecule 1; Endothelial leukocyte adhesion molecule 1; ESEL; LECAM 2; LECAM2; Leukocyte endothelial cell adhesion molecule 2; Le

Cat:

SL1273R

Species Reactivity：

Human,Mouse,Pig,(predicted: Rat,Chicken,Dog,Horse,Rabbit,)

Immunogen：

KLH conjugated synthetic peptide derived from mouse E-Selectin:501-612/612<Cytoplasmic>

Format：

Liquid

Storage instructions：

Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.

Concentration：

1mg/ml

Clonality：

Polyclonal

Isotype：

IgG

Applications：

WB=1:500-2000ELISA=1:5000-10000IHC-P=1:100-500IHC-F=1:100-500IF=1:100-500（Paraffin sections need to do antigen repair）not yet tested in other applications.optimal dilutions/concentrations should be determined by the end user.

Host：

Rabbit

Product Overview：

Sample: Siha Cell Lysate at 40 ugPrimary: Anti- E-Selectin (SL1273R) at 1/300 dilutionSecondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilutionPredicted band size: 65 kDObserved band size: 65 kDSample: Liver (Mouse) Lysate at 40 ugPrimary: Anti- E-Selectin (SL1273R) at 1/300 dilutionSecondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilutionPredicted band size: 65 kDObserved band size: 65 kDSample: HL-60 Cell (Human) Lysate at 40 ugPrimary: Anti- E-Selectin (SL1273R) at 1/300 dilutionSecondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilutionPredicted band size: 65 kDObserved band size: 65 kDSample: DU145 Cell Lysate at 40 ugLOVO Cell Lysate at 40 ugPrimary: Anti-E-Selectin (wt-p53)(SL1273R) at 1/300 dilutionSecondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilutionPredicted band size: 65 kDObserved band size: 63 kD

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Unit:

Price: $220.00

Product PDFs

Datasheet: Down Datasheet

Other Information
Citations
Protein Attributes
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The protein encoded by this gene is found in cytokine-stimulated endothelial cells and is thought to be responsible for the accumulation of blood leukocytes at sites of inflammation by mediating the adhesion of cells to the vascular lining. It exhibits structural features such as the presence of lectin- and EGF-like domains followed by short consensus repeat (SCR) domains that contain 6 conserved cysteine residues. These proteins are part of the selectin family of cell adhesion molecules. Adhesion molecules participate in the interaction between leukocytes and the endothelium and appear to be involved in the pathogenesis of atherosclerosis. [provided by RefSeq, Jul 2008]

Function:
Cell-surface glycoprotein having a role in immunoadhesion. Mediates in the adhesion of blood neutrophils in cytokine-activated endothelium through interaction with PSGL1/SELPLG. May have a role in capillary morphogenesis.

Subunit:
Interacts with PSGL1/SELPLG through the sialyl Lewis X epitope. PSGL1 sulfation appears not to be required for this interaction.

Subcellular Location:
Membrane; Single-pass type I membrane protein.

Similarity:
Belongs to the selectin/LECAM family.
Contains 1 SLCtype lectin domain.
Contains 1 EGF-like domain.
Contains 6 Sushi (CCP/SCR) domains.

SWISS:
Q00690

Gene ID:
20339

Database links:

Entrez Gene: 1281 Human

Entrez Gene: 20339 Mouse

Entrez Gene: 25544 Rat

Omim: 131210 Human

SwissProt: P16581 Human

SwissProt: Q00690 Mouse

SwissProt: P98105 Rat

Unigene: 82848 Human

Unigene: 5245 Mouse

Unigene: 10359 Rat

E选择素(CD62E)是活化的内皮细胞表面表达的黏附分子,是白细胞与内皮细胞形成接触时的启动因子。E选择素是表达在血管内皮细胞表面的黏附分子。 Picture

Sample: Liver (Mouse) Lysate at 40 ug
Primary: Anti- E-Selectin (SL1273R) at 1/300 dilution
Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution
Predicted band size: 65 kD
Observed band size: 65 kD

Sample: HL-60 Cell (Human) Lysate at 40 ug
Primary: Anti- E-Selectin (SL1273R) at 1/300 dilution
Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution
Predicted band size: 65 kD
Observed band size: 65 kD

Sample:
DU145 Cell Lysate at 40 ug
LOVO Cell Lysate at 40 ug
Primary: Anti-E-Selectin (wt-p53)(SL1273R) at 1/300 dilution
Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution
Predicted band size: 65 kD
Observed band size: 63 kD

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Specific References (16) | SL1273R has been referenced in 16 publications.

[IF=3.96] Zhang, Zhuochao, et al. "Cytokine profiles in Tibetan macaques following α‐1, 3‐galactosyltransferase‐knockout pig liver xenotransplantation." Xenotransplantation (2017). IHSLCP ; Pig.

PubMed:28714241

[IF=5.118] Masahiro Terasawa. et al. Anti-Inflammatory Activity of Orally Administered Monostroma nitidum Rhamnan Sulfate against Lipopolysaccharide-Induced Damage to Mouse Organs and Vascular Endothelium. Mar Drugs. 2022 Feb;20(2):121 IHC ; Mouse.

PubMed:10.3390/md20020121

[IF=3.512] Wen Xiong. et al. Mechanisms and Molecular Targets of BuShenHuoXue Formula for Osteoarthritis. Acs Omega. 2022;7(5):4703–4713 WB ; Rat.

PubMed:35155962

[IF=4.545] Zhixiong Li et al. Shuxuening injection facilitates neurofunctional recovery via down-regulation of G-CSF-mediated granulocyte adhesion and diapedesis pathway in a subacute stroke Mousemodel. Biomed Pharmacother. 2020 Jul;127:110213. WB ; Mouse.

PubMed:32417690

[IF=2.976] Peng Y et al. Sonodynamic therapy improves anti‑tumor immune effect by increasing the infiltration of CD8+ T cells and altering tumor blood vessels in murine B16F10 melanoma xenograft. Oncol Rep. 2018 Oct;40(4):2163-2170. IHF ; Mouse.

PubMed:30106435

[IF=3.74] Zhang, Shengye, et al. "Role of the plasma cascade systems in ischemia/reperfusion injury of bone." Bone (2017). IHSLCP ; Rat.

PubMed:28159709

[IF=3.38] Chou, Kang-Ju, et al. "CD44 Fucosylation on Mesenchymal Stem Cell Enhances Homing and Macrophage Polarization in Ischemic Kidney Injury." Experimental Cell Research (2016). WB ; Mouse.

PubMed:27871849

[IF=3.99] Naito, Chisato, et al. "Facilitatory effects of fetuin-A on atherosclerosis."Atherosclerosis (2016). WB ; Human.

PubMed:26828753

[IF=2.02] Kong, Lingxi, et al. "The anti-inflammatory effect of kaempferol on early atherosclerosis in high cholesterol fed rabbits." Lipids in Health and Disease 12.1 (2013): 115. IHSLCP ; Rabbit.

PubMed:23895132

[IF=1.287] Na Li. et al. SELE gene as a characteristic prognostic biomarker of colorectal cancer:. J Int Med Res. 2021;49(4): IHC ; Human.

PubMed:33845603

[IF=5.201] Qian Liet al. LOX-1 Regulates P. gingivalis-Induced Monocyte Migration and Adhesion to Human Umbilical Vein Endothelial Cells. Front Cell Dev Biol . 2020 Jul 14;8:596. WB ; Human.

PubMed:32793587

[IF=4.556] Chou K et al. Secretome of Hypoxic Endothelial Cells Stimulates Bone Marrow-Derived Mesenchymal Stem Cells to Enhance Alternative Activation of Macrophages. Int J Mol Sci. 2020 Jun 21;21(12):889. Other ; Mouse.

PubMed:32575834

[IF=4.486] Wang X et al. Crosstalk between Akt and NF‐κB pathway mediates inhibitory effect of gas6 on monocytes‐endothelial cells interactions stimulated by P. gingivalis‐LPS. J Cell Mol Med . 2020 Jul;24(14):7979-7990. WB ; Human.

PubMed:32462812

[IF=0] Wei, Min Jun, et al. "Identification of OPN, TNC and E-selectin as potential recognition proteins in cerebral vasospasm after subarachnoid hemorrhage."Chinese Neurosurgical Journal 2.1 (2016): 1. WB, IHSLCP ; Human, Rat.

PubMed:10.1186/s41016-016-0035-6

[IF=0.14] Tu, Q., et al. "Atorvastatin protects against cerebral ischemia/reperfusion injury through anti-inflammatory and antioxidant effects." Neural Regeneration Research 9.3 (2014): 268. IHSLCP ; Rat.

PubMed:25206811