The protein encoded by this gene is a G protein-coupled receptor that interacts with the patched protein, a receptor for hedgehog proteins. The encoded protein tranduces signals to other proteins after activation by a hedgehog protein/patched protein complex. [provided by RefSeq, Jul 2010]
Function:
G protein-coupled receptor that probably associates with the patched protein (PTCH) to transduce the hedgehog's proteins signal. Binding of sonic hedgehog (SHH) to its receptor patched is thought to prevent normal inhibition by patched of smoothened (SMO). Required for the accumulation of KIF7 and GLI3 in the cilia.
Subunit:
Interacts with ARRB2. Interacts with KIF7.
Subcellular Location:
Membrane.
Similarity:
Belongs to the G-protein coupled receptor Fz/Smo family.
Contains 1 FZ (frizzled) domain.
SWISS:
Q99835
Gene ID:
6608
Database links:
Entrez Gene: 6608 Human
Entrez Gene: 319757 Mouse
Entrez Gene: 25273 Rat
SwissProt: Q99835 Human
SwissProt: P56726 Mouse
SwissProt: P97698 Rat
Unigene: 437846 Human
Unigene: 29279 Mouse
Unigene: 44429 Rat
|
|
